Oxidative stress, antioxidant status and lipid profile in ischemic heart disease patients from western region of Nepal (original) (raw)
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High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease
Hypertension, 2000
Treatment of high blood pressure (BP) has not produced the expected reduction in risk of ischemic heart disease (IHD). Subjects with high BP often have the metabolic syndrome X, an aggregation of abnormalities in glucose and lipid metabolism. We tested the hypothesis that the BP level would be less predictive of risk of IHD in those with high triglycerides (TG) and low HDL cholesterol (HDL-C), the characteristic dyslipidemia in the metabolic syndrome than in those without. Baseline measurements of fasting lipids, systolic BP (SBP), diastolic BP (DBP), and other risk factors were obtained in 2906 men, age 53 to 74 years, free of overt cardiovascular disease. High TG/low HDL-C was defined as TG Ͼ1.59 mmol/L and HDL-C Ͻ1.18 mmol/L. Within an 8-year period, 229 men developed IHD. In men with high TG/low HDL-C, the incidence of IHD according to SBP (Ͻ120, 120 to 140, Ͼ140 mm Hg) was 12.5%, 12.9%, and 10.0% (PϭNS), respectively, and according to DBP, the incidence of IHD was (Ͻ75, 75 to 90, Ͼ90 mm Hg) 13.7%, 10.6%, and 13.7% (PϭNS), respectively. The corresponding figures for other men were 5.2%, 8.0%, and 9.7% for SBP (PϽ0.001), and 6.1%, 7.5%, and 9.9% for DBP (PϽ0.03). In conclusion, the BP level did not predict the risk of IHD in those with high TG/low HDL-C. This finding may explain the reason lowering BP has not produced the expected reduction in IHD.
Lipid profiles of non-diabetic healthy and ischaemic heart disease patients
Objective: To find any difference in the fasting lipid profile in patients with history of ischaemic heart disease (IHD) and established atherosclerotic plaques on angiography and in subjects with no known history of IHD. Study Design: Observational, cross-sectional study. Place and Duration of Study: Immunology Department of University of Health Sciences, Lahore, from January 2007 to January 2009. Methodology: In this study, 200 male subjects, between 40 and 60 years of age were recruited. Serum cholesterol and triglycerides were determined by enzymatic CHOD-PAP and GPO-PAP calorimetric method, HDL-C by accelerator selective detergent method and LDL-C by direct homogeneous enzymatic method. Serum ox-LDL contents were determined by using quantitative sandwich enzyme immuno-assay kits. Results: The total serum cholesterol, triglyceride and LDL-C levels were within the normal range in control and patient groups whereas HDL-C levels were significantly higher in the control group compar...
LIPID PROFILE OF PATIENTS WITH ISCHAEMIC HEART DISEASE FROM RURAL AREA OF MARTHAWADA REGION, INDIA
Background: Extensive research work by mankind over several decades has concluded that cure as well as the treatment of CAD is very difficult hence attention towards prevention of such ischemic events is of utmost importance. Methods: The present study was conducted with an aim to study lipid profile of patients of Ischemic Heart Disease (IHD).in comparison with healthy controls. A total of 150 IHD patients for the study were selected from the Medicine Ward, ICU, and OPD. Normal healthy person of matched number, age and sex of the study group were used as control. Results: Serum cholesterol, TG, VLDLc, LDLc and AIP were significantly higher in IHD patients as compared to healthy controls. Conclusion: Lipid profile is very useful research tool to assess the effect of risk factors pertaining cardiovascular diseases.
Acute Myocardial Infarction Risk Factors and Correlation of its Markers with Serum Lipids
Journal of Applied Biotechnology & Bioengineering, 2017
Myocardial infarction is a term applied to myocardial necrosis secondary to an acute interruption of the coronary blood supply. Atherosclerosis is by far the most common cause of myocardial infarction. According to the INTERHEART study report, nine factors are responsible for 90% of myocardial infarctions. Modifiable risk factors include Diabetes mellitus, smoking, hypertension, hyperlipidemia, sedentary life style, obesity, stress and depression. The combination of several risk factors further enhances the risk. This study aimed to evaluate the frequency of risk factors among AMI patients in Tajoura National Heart Center, Libya, and to detect the presence of correlation between AMI markers and serum lipids. This study was conducted from September, 2007 to April, 2008. On 120 acute myocardial infarction patients, 86 males and 34 females, and the results were compared to the results of 40 healthy persons (20 male and 20 female) with matched ages with the patients. The results of this study concluded that, ages of most male patients were from 45-65 years old, but most of female ages from 55-75 years old which means that, the incidence of AMI was occurred in males earlier than females. The most prevalent risk factor in male and female patients is diabetes. Smoking is the second risk factor in males, and hypertriglyceridemia was the second risk factor among female patients. The study was also showed correlation between total CK and CK-MB and total cholesterol concentration, but this was not found between LDH, TN-t and cholesterol, on the other hand, LDH was correlated with HDLC.
2020
Coronary Heart Disease (CHD) is the leading cause of death worldwide. CHD preceded by the atherosclerosis process. Ox-LDL, LDL, and HDL cholesterol may be more potent biomarkers for predicting and diagnosing CHD than those only conventional measurements of lipid levels with the Framingham Risk Score (FRS). Purpose to determine the correlation between Ox-LDL, LDL, HDL levels and FRS in a population at risk of CHD This study was an analytical descriptive with a cross-sectional research design. The research subjects were 143 (79 male and 64 female) subjects. Serum Ox-LDL, LDL, HDL levels were checked by Sandwich ELISA method. FRS includes gender, age, total cholesterol, HDL-cholesterol, systolic blood pressure, history of taking antihypertensive drugs, smoking, diabetes, and vascular disease (CHD, Stroke). Ox-LDL and HDL levels had a very weak negative correlation to FRS (p = 0.017; r = -0.199; p = 0.000; r = -0.305) and had a very weak effect (R=0.174, R2=3%; R= 0.283, R2=8%). Levels ...
Evaluation of Oxidative Stress Status in Familial Hypercholesterolemia
Journal of Clinical Medicine, 2021
Background: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder characterizied by elevated levels of circulating low-density lipoprotein cholesterol (LDL-C) which is an important source of substrates to be oxidized by different oxidative agents. Subsequently, the oxidized LDLs (oxLDLs) induce further oxidative reactions in FH patients, which contributes to the development of atherosclerosis and advanced cardiovascular events in these patients. This study aimed to investigate the association of oxidant/antioxidant markers with FH. Methods: This case-control study comprised 18 HoFH, 18 HeFH, and 20 healthy subjects. Oxidant/antioxidant markers including MDA, MPO, thiol, nitric oxide (NO), myeloperoxidase (MPO), glutathione peroxidase (GPx), SOD, and CAT were assessed by colorimetric methods. Prooxidant-antioxidant balance was also measured by pro-oxidant antioxidant balance (PAB) assay. Results: The levels of MDA (p < 0.001), MPO activity (p < 0.001), thiol (p < 0.001), NO (p < 0.01), and PAB (p < 0.001) were notably higher in HoFH group in comparison with healthy subjects. HeFH group also showed significantly higher levels of thiol (p < 0.001) and PAB (p < 0.001) when compared to healthy subjects. Elevated levels of MDA (p < 0.001) and PAB (p < 0.001) were also observed in HoFH relative to HeFH. No significant differences were found between the studied groups in the case of antioxidant enzyme activities. The results of binary logistic regression showed that PAB (OR: 0.979; p = 0.033), and MDA (OR: 0.996; p = 0.018) levels were inversely associated with HoFH, although, after adjustment for age and LDL-C levels, these associations were diminished. Conclusion: Several oxidant/antioxidant differences were found between FH patients and healthy individuals as well as between HoFH and HeFH patients. These differences might be strongly dependent on plasma LDL-C levels.
Kinetic analysis of LDL oxidation in IHD and IHD risk subjects in Indian population
Indian Journal of Clinical Biochemistry, 2003
High plasma concentration of low-density lipoprotein (LDL) is associated with increased risk of atherosclerosis. Modified forms of LDL, especially oxidized LDL play a major role in its pathogenesis. This article gives detailed insight into the kinetics of in vitro LDL oxidation by copper at different concentrations in normal and high-risk group subjects. Basal level of oxidatively modified LDL was significantly higher in ischaemic heart disease (IHD) and IHD hyperlipidemic subjects compared to normolipidemic and hyperlipidemic control subjects, respectively. Derivatization of amino groups of apo-lipoprotein as monitored by estimating free amino groups concentration, was significantly higher in high-risk group and established IHD cases. Kinetics of oxidation was studied with two different concentrations of CuSO 4 (2.5 mM and 7.5 mM). Thiobarbituric acid reactive substances (TBARS) level increased with time, and up to 95% oxidation was observed in 8 hr. About 60-65% less free amino groups were observed in native-LDL isolated from IHD patients compared to normal subjects. Study also showed an increase in two oxidative products studied, 20(~-OH-cholesterol and 4-cholesten-3-one with oxidation time accompanied by corresponding decrease in LDL cholesterol. Increase in oxidative species was more evident in high-risk group and IHD patient. Basal level of oxidatively modified LDL measured in terms of TBARS was significantly higher in present study, strongly support that the extent of LDL oxidation monitored as TBARS and FAG level in circulating-LDL could be used as risk marker for high risk group.
A study of lipid levels in Indian patients with coronary arterial disease
International Journal of Cardiology, 1989
S, Prasad NK, Jose VJ. A study of lipid levels in Indian patients with coronary arterial disease. Int J Cardiol 1989;24:337-345. A detailed cross-sectional analysis of total cholesterol and triglyceride levels was studied in 1066 consecutive male patients who underwent selective coronary arteriography in our centre to confirm or exclude coronary arterial disease. There were 877 cases of coronary arterial disease and 189 patients with normal coronary arteries. Besides descriptive statistics of lipid levels in different age groups, percentile distribution was studied. Association characteristics between lipids and other risk factors was studied by multiple regression analysis. Relative risk of lipids, controlling for the confounding variable of age as well as weight was obtained using the Mantel Haenszel chi square procedure. Results revealed the occurrence of coronary artery disease with low lipid levels in our population. The 50th percentile for total cholesterol was 205 mg/dl for the cases and 186 mg/dl for controls, while for triglycerides it was 158 mg/dl for cases and 140 mg/dl for controls. Multiple regression analysis of smoking, positive family history, diabetes, hypertension, weight and age contributed a low R square value of 2.49% for cholesterol and 4.22% for triglycerides in the cases and controls. The Mantel Haenszel chi square test procedure confirmed that low lipid levels could be seen irrespective of the age or weight of individuals. It is speculated that other factors which may include ageing, metabolic or immunologic components yet to be ascertained, could contribute additionally, to atherosclerotic coronary arterial disease in our population.
Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study
Neurology, 2015
Objectives: To examine the relationship between plasma lipid measurements and incident ischemic vascular events (ischemic stroke [IS], and as a positive control, myocardial infarction [MI]) in a community cohort. Methods: In 6,276 stroke-free Framingham participants (aged 64 6 10 years, 56% female), we related plasma lipid levels (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], and TC/HDL-C ratio) measured at the original cohort 15th (1977-1979) and 20th examination cycles (1986-1990) and (TC, HDL-C, TC/HDL-C ratio, triglycerides [TG], and low-density lipoprotein cholesterol [LDL-C]) measured at the offspring fourth examination (1995-1998), to 10-year risk of incident IS and MI. Utilizing genome-wide genotyping in the same subjects, we used mendelian randomization methods to assess whether observed associations were incidental or causal. Results: During a mean follow-up of 9 years, 301 participants experienced incident IS. In multivariable-adjusted analyses, HDL-C #40 mg/dL and TC/HDL ratio $5 were associated with increased risk of IS (hazard ratio [95% confidence interval]: 1.59 [1.23-2.05], p , 0.001 and 1.47 [1.15-1.87], p , 0.001), but not TC or LDL-C. In adjusted analysis, a strong association between TG and IS was diminished. In the MI-free sample (n 5 5,875, aged 64 6 10 years, 58% female; 403 MI events), all lipid markers were associated with MI risk. A genetic risk score comprising 47 known determinants of circulating HDL-C was not associated with IS. Conclusions: In a middle-aged to elderly community sample, we observed that low HDL-C and high TC/HDL-C ratio, but not LDL-C or TG were associated with risk of incident IS. We observed the usual associations between lipids and risk of MI. Our findings suggest an important, but less likely causal, role of HDL-C over other lipid biomarkers for optimal stroke risk stratification.