A rare case of uterine leiomyosarcoma: A case report (original) (raw)
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Uterine leiomyosarcoma: A case report
Journal of Mid-life Health, 2014
Uterine leiomyosarcoma is a rare uterine malignancy that arises from the smooth muscles of uterine wall. It accounts for only 1-2% of uterine malignancies. We report a case of a 60-year-old female who presented with postmenopausal bleeding and was diagnosed later to be a case of leiomyosarcoma of uterus. The diagnosis of leiomyosarcoma is made by histopathological examination, and surgery is the only treatment. The prognosis for female with uterine sarcoma primarily depends on the extent of disease at the time of diagnosis and the mitotic index.
Leiomyosarcoma of the Uterus: A Rare Diagnosis
Cureus, 2021
Uterine leiomyosarcoma is a rare malignant tumor that accounts for almost 2-5% of all uterine malignancies. It has the highest prevalence during pre and perimenopause. Further, it clinically resembles benign conditions like leiomyoma, and the diagnosis is confirmed with the histologic findings of the mass. Here, we present the case of a 70-year-old female who presented with lower abdominal pain for two years. Exploratory laparotomy with hysterectomy was performed, and the diagnosis of leiomyosarcoma was confirmed after histological examination of the resected tumor.
Uterine Leiomyosarcoma: A Case Report and Review of Relevant Literatures
Journal of Advances in Medicine and Medical Research
Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Leiomyosarcoma is a malignant lesion of smooth muscle origin. This is a rare lesion in the uterus with 1-2 % of its benign counterpart, leiomyoma, transforming into the lesion. It is often aggressive and could develop at any site where the smooth muscle is found. We present a case of a 48-year-old farmer with pelvic mass with Ultra-sonography(USS) suggestive of leiomyoma. Hysterectomy was done and histologic diagnosis of leiomyosarcoma (LMS) was made. The patient was discharged 7 days post operation but was lost to follow up. Uterine LMS is an aggressive tumour, therefore, a high index of suspicion is needed especially for huge uterine nodules and such patients must be closely monitored for adequate management.
The uterine leiomyosarcoma (LMS) is a rare sarcoma arising from the smooth muscle cells found within the myometrium, it is clinically aggressive smooth muscle malignancy, accounting for 2% to 6% of uterine malignancies and an annual incidence of 1.7 per 100,000 women. Although uterine malignancies such as endometrial cancer are common, uterine LMS accounts for only 1% of uterine cancers and is a part of uterine sarcomas' group, who comprises: carcinosarcoma (formerly known as MMMT, malignant mixed Mullerian tumor) (40% to 50%), leiomyosarcoma (30% to 40%) and endometrial stromal sarcoma (10% to 15%). Every group has its own risk factors, presenting symptoms, treatment response and prognosis. 1 Uterine smooth muscle tumors arise from the uterine myometrium and include leiomyomas (or fibroids) and uterine LMS, who exhibits histological features similar to that observed in soft tissue leiomyosarcomas. In fact, smooth muscle cell tumours may be divided into three groups: benign (leiomyoma), malignant (leiomyosarcoma), and tumors of unknown malignant potential. 2
A Rare Case Report of Uterine Leiomyosarcoma in young age
IOSR Journals , 2019
Leiomyosarcoma is a rare malignancy of smooth muscle origin, notorious for it's aggressive nature and poor prognosis. Uterine leiomyosarcoma accounts for 1% of all uterine malignancies. Here we are presenting a rare case of uterine leiomyosarcoma at a young age of 29 years. She is para one with one living issue, underwent lower segment caesarean section, had complaints of continuous bleeding per vaginum and lower abdominal pain for 5months. Initially, she was managed conservatively as intramural fibroid. Later, the patient presented with continuous bleeding per vaginum with severe breathlessness diagnosed as Uterine Leiomyosarcoma stage IVB with lung metastasis.
Uterine leiomyosarcoma in a premenopausal woman Clinical case 1
American Journal of Medical and Clinical Research & Reviews, 2023
INTRODUCTION. Leiomyosarcoma (LMS) of the uterus is a rare soft-tissue tumor of the female pelvis with <1% of uterine tumor. It usually arises from the uterine myometrium de novo or is very rarely transformed from a preexisting benign leiomyoma. These tumors are found mainly in females 40-60 years of age. Leiomyomas seen in the reproductive age group and a strong suspicion of LMS should be in mind in cases of fibroid with postmenopausal bleeding. CLINICAL CASE. A 39-year-old female came to the emergency room complaining of pelvic pain of 8 days duration, treated symptomatically with NSAIDs. It has the following background: hereditary family history, which is unimportant to the case. Gynecobstetric history: menarche 11 years old, regular cycles five to seven days, reports two months with uncontrolled cycle with heavy menstrual bleeding, start active sexual life 24 years old. Papanicolaou: last year reported normal; colposcopy last one and a half ago reported normal. DISCUSSION. Approximately 40-80% of women may develop leiomyomas, the most common benign gynecological disease, during their lifetime. Uterine sarcoma, on the other hand, is a rare disease with an incidence ranging from 1.55 to 1.95 per 100,000 women per year. According to the WHO, in 2011, a LMS is a specific type of rare sarcoma that accounts for over 60% of all cases of uterine sarcoma. It is
Advanced leiomyosarcoma of the uterus: a case report and literature review
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Uterine leiomyosarcoma is a rare malignancy accounting for 1-2% of uterine malignancies with an annual incidence of 0.5-7 per 100,000 women. It occurs mostly between the 5th to 7th decades of life hence found more among postmenopausal women. The aetiology is mostly unknown however, in 0.2% of cases, it originates from sarcomatous degeneration in a pre-existing benign uterine fibroid. Leiomyosarcoma can be mistaken for uterine leiomyoma also known as the uterine fibroid. It is an aggressive tumour that has a poor prognosis, with or without treatment. This case report aimed to report and discuss the occurrence of leiomyosarcoma as a differential diagnosis of abnormal uterine bleeding in this environment among other conditions. This will bring to the fore awareness among gynaecologists, pathologists, radiologists and oncologists that leiomyosarcoma of the uterus, though rare, should be considered in cases of menorrhagia with suspected uterine fibroid to avoid mistaking it for a diagn...
UTERINE LEIOMYOSARCOMA: About 13 Cases and Review of the Literature
Journal of medical biomedical and applied sciences, 2018
The uterine leiomyosarcoma (LMS) is a rare cancer arising from the smooth myometrial cells. The LMS is clinically aggressive malignancy, accounting for 2% to 6% of uterine malignancies and a very low annual incidence. Object of the study: To evaluate management and outcome of the treatment of uterine leiomyosarcoma. Patients and methods: Retrospective study of a series of 13 patients treated for uterine leiomyosarcoma in the department of radiotherapy of CHU Hassan II, Fes between 2012 and 2016 Results: The condition is rarely suspected preoperatively, diagnosis is usually made on histological examination of the operative specimen. The outcome is related to the mitotic activity of the tumour and to the infiltration of nearly structures. Surgery is the only effective treatment, chemotherapy is ineffective, adjuvant radiotherapy improves local control of the tumour but has no incidence on survival. Conclusion: In the absence of an effective adjuvant treatment, uterine leiomyosarcoma bears a poor prognosis with the only exception of small non infiltring tumours with a low mitotic activity.
European Clinics in Obstetrics and Gynaecology, 2005
The aims of the study were (1) to increase the limited knowledge on molecular markers contributing to uterine leiomyosarcoma (LMS) tumorigenesis and (2) to test the ability to predict the clinical course of smooth muscle tumors of low malignancy (SMTLM). Retrospectively, 2,360 uterine smooth muscle tumors were classified according to the Stanford criteria. After central review, the clinical course of
Open Journal of Radiology, 2014
Uterine leiomyoma is a relatively common condition occurring in a majority of African American and Caucasian women by age 50. Magnetic resonance imaging of the pelvis with contrast is the modality of choice when evaluating uterine tumors. We report a case of a patient with a four-day history of intra-menstrual vaginal bleeding who underwent magnetic resonance imaging of the pelvis that suggested the tumor was a leiomyosarcoma, the malignant counterpart of leiomyoma. Therefore, the patient underwent pre-operative uterine artery embolization to decrease blood loss with exploratory laparotomy, resection of pelvic mass and dilation and curettage. Pathologic evaluation of the mass returned a diagnosis of leiomyoma. Magnetic resonance imaging evaluation of leiomyomata remains difficult. Further development of imaging parameters could improve diagnosis of benign uterine fibroids.