Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors (original) (raw)
Advances in Design and Development of Inhibitors of Nitric Oxide Synthases
Current Enzyme Inhibition
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Structure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water
Pavel Martasek
Journal of Medicinal Chemistry, 2007
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Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron−Thioether Coordination Is Stabilized by Hydrophobic Contacts without Increased Inhibitor Potency
Tzanko Doukov, Huiying Li
Journal of the American Chemical Society, 2010
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Minimal amidine structure for inhibition of nitric oxide biosynthesis
D. M . Porterfield
Biochemical Pharmacology, 2001
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Crystallographic Studies on Endothelial Nitric Oxide Synthase Complexed with Nitric Oxide and Mechanism-Based Inhibitors †
Pavel Martasek
Biochemistry, 2001
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Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes
恒彦 樋口
Bioorganic & Medicinal Chemistry Letters, 2005
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A new class of selective and potent inhibitors of neuronal nitric oxide synthase
Dane Liston
Bioorganic & Medicinal Chemistry Letters, 1999
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Structural Characterization and Kinetics of Nitric-oxide Synthase Inhibition by Novel N5-(Iminoalkyl)- and N5-(Iminoalkenyl)-ornithines
Owen Griffith
Journal of Biological Chemistry, 2003
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1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
Subhash Annedi
Bioorganic & Medicinal Chemistry Letters, 2011
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Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase
Ana Castro, C. Gil
Bioorganic & Medicinal Chemistry, 2008
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Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges
Lukas Kubala
Mediators of Inflammation, 2012
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Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors
Pavel Martasek
Bioorganic & Medicinal Chemistry, 2007
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Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors
Dennis Stuehr
Journal of Biological Chemistry, 2001
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In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures
Jianguo Fang
Bioorganic & Medicinal Chemistry, 2013
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Characterization of Three Inhibitors of Endothelial Nitric Oxide Synthase In Vitro and In Vivo
Richard Alfred Palmer
British Journal of …, 1990
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Nitric Oxide: State of the Art in Drug Design
Current Medicinal Chemistry, Elizabeth Ferreira
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Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity
Georges Chreifi
Journal of Medicinal Chemistry, 2014
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Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases
P. Martasek
Bioorganic & Medicinal Chemistry, 1999
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Secondary amines containing one aromatic nitro group: Preparation, nitrosation, sustained nitric oxide release, and the synergistic effects of released nitric oxide and an arginase inhibitor on vascular smooth muscle cell proliferation
Dillip Mohanty
Bioorganic & Medicinal Chemistry, 2013
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Antonio Mete
Bioorganic & Medicinal Chemistry Letters, 2011
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Selective Inhibition of Neuronal Nitric Oxide Synthase by N ω -Nitroarginine- and Phenylalanine-Containing Dipeptides and Dipeptide Esters
Michael Marletta
Journal of Medicinal Chemistry, 1997
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The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase
Marc Whitlow
Bioorganic & Medicinal Chemistry Letters, 2007
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Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by N ω -Allyl- l -Arginine
Robert Dixon
Journal of the American Chemical Society, 1997
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Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability
Jianguo Fang, Fengtian Xue
Bioorganic & Medicinal Chemistry Letters, 2010
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De Novo Design of Potent and Selective Neuronal Nitric Oxide Synthase (nNOS) Inhibitors by a Fragment-Based Approach
Kemal Yelekci
JOURNAL OF PHARMACEUTICAL CHEMISTRY, 2015
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