Computed tomography: a new method for diagnosing tumor of the heart (original) (raw)
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Secondary cardiac tumors are 20-40 times more frequent than primary lesions. Primary cardiac lesions are represented by myxomas when related to benign tumors, and by sarcomas in terms of malignant disease . Melanoma, breast carcinoma, lung carcinoma, and lymphoma, in that order, are the most common tumors metastasizing to the heart [4], whereas the incidence of sarcoma has been shown to be 0.6% in one autopsy series of patients with malignancy [5].
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Cardiac liposarcoma is an uncommon tumor with a poor prognosis. The diagnosis and surgical treatment of this malignant tumor are the subject of this review.
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Postgraduate Medical Journal, 1986
A rare form ofprimary heart tumour, a liposarcoma, is reported. A discussion of diagnosis and modalities of treatment of primary heart sarcomas is presented.
Journal of Cardiovascular Medicine, 2008
Cardiac neoplasms, whether primary or secondary, are more and more easily diagnosed in the present era. For the primary heart tumors, myxomas and sarcomas constitute the most common neoplasms, whereas for the secondary ones, lung cancer constitutes the most common primary location. Cardiac neoplasms may involve the endocardium, the myocardium, the epicardium, the valves or any combination of these. Their clinical manifestations are not specific and depend on their anatomic location and size. Diagnosis of cardiac neoplasms has become more feasible with the use of echocardiography and other imaging techniques (computed tomography and magnetic resonance). The major problem, however, still remains that most diagnoses are late, especially for malignant tumors. For resectable tumors, surgery remains the mainstay of treatment, whereas for metastatic disease palliative treatment remains the only therapeutic option. This paper reviews the types of heart tumors, their clinical symptoms, the diagnostic approaches and the therapeutic tools used by physicians.
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A young male who presented with atypical chest pain was found to have a primary cardiac tumor. Chest X-ray, electrocardiogram, and echocardiographic findings can be nonspecific. Differential diagnosis and the role of different diagnostic modalities including echocardiogram, computerized tomography and magnetic resonance imaging are discussed.
Pleomorphic Liposarcoma Presenting as Extracardiac Mediastinal Mass Leading to Cardiac Compression
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A 45-year-old male presented with a 3-month history of fever associated with dyspnea, orthopnea, weight loss, chest pain, and anorexia. Past history was notable for cigarette smoking of 5 packs per year. Examination findings suggested clubbing, raised jugular venous pulse and pedal edema. Characteristic findings on systemic examination were displaced apex beat, sternal heave, bibasilar crepitations, distended abdomen, and presence of shifting dullness. Echocardiography revealed an extracardiac mass collapsing mostly the right side of the heart. Later, multidetector computed tomography scan (MDCT) was done which detected a mediastinal mass crossing midline, significantly compressing right sided cardiac chambers, adjacent segments of major arteries and veins, and displaced esophagus to the left. An ultrasound guided biopsy confirmed the diagnosis of pleomorphic liposarcoma. Although it turned out to be a surgical case, but the objective of reporting this case of pleomorphic liposarco...
Archivos de CardiologĂa de MĂ©xico, 2019
Liposarcomas represent the second most common type of soft tissue sarcomas after malignant fibrous histiocytoma. There are four histological subtypes according to the World Health Organization: well-differentiated (atypical lipomatous) liposarcoma, dedifferentiated, myxoid (round-cell) liposarcoma (ML), and pleomorphic liposarcoma 1. Their primary anatomical sites of origin from liposarcomas are the retroperitoneum in 25-50% and the lower limbs in 25-35%. The most frequent distant sites for metastasis arising from ML include lungs, retroperitoneum, abdominal cavity, and chest wall 1. ML accounts for 30-50% of all liposarcomas, with a peak incidence between the third and the fifth decade of life, being more frequent in males than females, exhibiting an overall metastatic rate of 30%. Interestingly, it has an expansive growth pattern, with less aggressive infiltrative behavior, thus, causing frequently obstructive clinical syndromes at the main site of metastasis, however, metastatic intracardiac soft tissue sarcomas represent an extremely rare clinical
Invasive Cardiac Lipoma: a case report and review of literature
BMC Cardiovascular Disorders
Background: Cardiac lipomas are rare benign tumors of the heart. They are usually asymptomatic and are thus most often diagnosed on autopsies. Symptoms, when present, depend upon the location within the heart. Typical locations are the endocardium of the right atrium and the left ventricle. Diagnostic modality of choice is cardiac MRI. Treatment guidelines have not yet been established due to the very low prevalence of these tumors and are thus guided by the patient's symptomatology. Case presentation: We describe a case of an invasive cardiac lipoma, wherein the initial symptom of the patient was shortness of breath. Although the echocardiogram visualized the tumor in the right atrium, a cardiac MRI was performed for better tissue characterization. The MRI revealed a large, fat containing, septated mass in the right atrium with invasion into the inter-atrial septum and inferior cavoatrial junction. There was also invasion of the coronary sinus along the inferior and left lateral aspect of the posterior atrioventricular groove. Although the mass appeared to represent a lipoma by imaging characteristics, the unusual extension into the coronary sinus led to consideration of a low-grade liposarcoma in the differential. Thus a pre-operative biopsy was performed along with MDM2 gene amplification to rule out a liposarcoma preceding surgical excision. Conclusion: Cardiac lipomas are well-characterized on cardiac MRI, which is the diagnostic modality of choice. Typical locations are the right atrium and the left ventricle. However, in those with atypical features such as invasion of the coronary sinus, pre-operative biopsy for histopathologic confirmation is imperative to exclude well-differentiated liposarcoma. Our patient with a simple lipoma underwent partial resection to relieve symptoms. We discuss prognosis and treatment of symptomatic cardiac lipomas.