Therapeutic Efficacy of Urinile Against Gouty Arthritis (original) (raw)
Related papers
2012
Introduction-Hyperuricemia (solubility point of Mono Sodium Urate Crystal i.e. 7.1 mg/dl) is associated with gout and present in 0.2 to 2% of Indian popultion. EULAR has published the guidelines for the diagnosis of gout based on evidences. In this study, we tried to evaluate clinical correlation of arthralgia with serum uric acid level in Indian patients and benefit from Allopurinol treatment. Material and Methods-Study design - Prospective, open labeled single arm Study carried out in Hospital attached to Medical University. Exclusion Criteria were Patients having definitive diagnosis for the etiology of arthralgia or Definitive Gout by clinical diagnosis as per EULAR recommendation. Inclusion criteria were Patients having the history of use of analgesic with persistent symptoms, having less than 4 EULAR criteria for gout and willing to be enrolled in the study. Intervention - Allopurinol 100 mg twice a day was given to patients and clinically assessed on day 1, day 10 and at 4 we...
Feasibility of a Strategy to Prevent Gouty Arthritis Through Limiting Crystallization of Monosodium
2018
Background: Crystallization of monosodium urate (MSU) is the cause of gout as well as is the cause of about 10% of kidney stones. The focus of this paper is on altering the crystallization of MSU, which occurs in the affected joint space. It is generally accepted that the inflammation caused by the MSU crystals leads to the clinical signs of gout: swelling, redness, and pain. Developing treatment and prevention strategies are hampered by not knowing the exact mechanisms. It is known, however, that the inflammatory phase can be controlled by limiting the size and amount of crystals formed. It is also known that only 2 to 36% of hyperuricemic individuals get gout; suggesting that there are chemicals found in the body that can prevent or limit crystallization in hyperuricemic individuals. This study was designed to look at the ability of various chemicals to modify the crystallization of MSU. Methods and Findings: It was found that vitamins (riboflavin, pyridoxine HCL, and β-carotene),...
Journal of Research in Ayurvedic Sciences, 2017
Background Vatarakta vis-à-vis gout is a common condition in both primary care and specialist practice. Gout is a systemic disease characterized by manifestations of chronic underlying hyperuricemia, resulting in the deposition of monosodium urate crystals in various tissues. Gout is the most common of the crystal induced arthritis due to disturbed uric acid metabolism and precipitation of urate crystals in extracellular space of joints, periarticular tissue, bones, and other organs. Aim and objective To explore the therapeutic efficacy and safety of Amrita Guggulu and Pinda Taila in the management of hyperuricemia in gout (Vatarakta) patients. Materials and methods A total of 100 cases (25–65 years) of primary gouty arthritis fulfilling the diagnostic criteria as recommended by the American College of Rheumatology were selected for the present study from outpatient department of the Central Ayurveda Research Institute for Respiratory Disorders Patiala and Regional Ayurveda Researc...
Review on Treatment of Gout & Hyperuricemia
Journal of Bangladesh …, 2011
In the last few decades, both hyperuricemia and gout have increased markedly. Recent studies show new concept into the transporters that handle uric acid in the kidney as well as possible links between these transporters & hyperuricemia. There are changes in the treatment of established hyperuricemia. Febuxostat and PEGuricase are two novel treatments that have been evaluated and shown to be highly effective in the management of hyperuricemia. Monosodium urate (MSU) crystals are the inducers of inflammation. Within the joint, they trigger a local inflammatory reaction, neutrophil recruitment, and the production of proinflammatory cytokines as well as other inflammatory mediators. The uptake of MSU crystals by monocytes involves interactions with components of the innate immune system. The inflammatory effects of MSU are IL-1-dependent and can be blocked by IL-1 inhibitors. These advances in the understanding of hyperuricemia and gout provide new therapeutic targets for the future.
Revista de Chimie
Acute gouty arthritis represents an inflammatory response to microcrystals of monosodium urate that precipitate in joint tissues from supersaturated body fluids or are shed from preexisting articular deposits [1]. Gout is a metabolic disease characterized by recurrent episodes of arthritis associated with the presence of monosodium urate crystals in the tissue or synovial fluid during the attack.These forms of crystal-induced arthritis usually affect peripheral joints, including knee, ankle, wrist, and metacarpophalangeal and metatarsophalangeal joints. All of them may be associated with other inflammatory, endocrine diseases [2]. The present study was done to highlight the relationship between increased levels of uric acid and specific laboratory tests in order to possible forecast development of further disease in patients with gouty arthrithis.The present study was done on 34 patients hospitalized in Felix Hospital of Rehabilitation in 2015-2016, with age between 44 and 74, havin...
Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice
BMC Complementary and Alternative Medicine
Background: Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. Method: An MSU crystal suspension (4 mg/50 μL) was injected intradermally into the right paw. The mice were orally administered MPE (150 mg/kg or 300 mg/kg) or the positive control drug colchicine (1 mg/kg) 1 h before the MSU crystals were injected and then once daily for 3 days. The effects of MPE included inflammatory paw edema and pain upon weight-bearing activity, and we evaluated the inflammatory cytokine expression and paw tissue inflammation-related gene expression. Results: MPE suppressed inflammatory paw edema and pain in the MSU-induced mice. MPE showed antiinflammatory activity by inhibiting the production of TNF-α, interleukin (IL)-1β, NLRP3 inflammasome and NF-κB. Conclusion: These results suggest that MPE has potent anti-inflammatory activities and may be useful as a therapeutic agent against gouty arthritis.
Evaluation of Allopurinol (Xanthine Oxidase Inhibitor) inManagement of Primary Gout (Niqras)
2020
Gout is the most prevalent crystals-induce arthropathy and is associated with impaired health-related quality of life. It is characterized by hyperuricemia and recurrent attacks of acute arthritis, often eventually associated with urate deposits in the tissues which may be manifest as tophi. Several studies suggest that its prevalence and incidence have risen in recent decades. The objective of present trial was to validate and to assess the efficacy and safety of Xanthine-oxidase inhibitor drugAllopurinol on the patients of primary gout. The study was of 18 months and designed as a randomized open-label with a sample size of 30 patients. The progress in subjective parameters was evaluated weekly, and at the baseline, fifteen days and thirty days in objective parameter. On the basis of severity, the subjective parameters were ranked arbitrarily from 03. There was observed a considerable improvement in subjective as well as objective parameters and no undesirable effect during and at...
Treating to target: a strategy to cure gout
2009
Acute gout attacks and the long-term complications of gout are associated with the deposition of monosodium urate (MSU) monohydrate crystals in the joints and soft tissues, causing acute and chronic inflammation. The aim of long-term treatment is to reduce the serum urate (sUA) level to 6 mg/dl (4360 mol/l), below the saturation point of MSU, so that new crystals cannot form and existing crystals are dissolved. Serial joint aspiration studies confirmed the disappearance of crystals with effective urate-lowering therapy. There is good evidence that achieving sUA <6 mg/dl (360 mol/l) results in freedom from acute gout attacks, and shrinkage and eventual disappearance of tophi. Gout patients must be informed about their diagnosis and educated about gout management including the importance of compliance with long-term treatment. Patients starting urate-lowering therapy need to understand the importance of prophylactic therapy with colchicine or NSAIDs to reduce the risk of 'mobilization flares' in the first few months. In the long term, reduction in the sUA below the target level will result in gout being effectively cured.
[ABSTRACT] Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs (MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate (MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mRNA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaOS-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators (IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mRNA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.