Antioxidant and Hepatoprotective Effects of Polygonum bistorta Linn. and Tannic Acid on Carbon Tetrachloride-treated Rats (original) (raw)

The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the aqueous extract of the roots of Polygonum bistorta Linn. (100 mg/kg) and tannic acid (25 mg/kg) in rats treated with carbon tetrachloride (0.15 ml/kg, i.p.). Plant extract and TA at the tested doses restored the levels of all serum (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin, total bilirubin and total protein) and liver homogenate enzymes superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase and drug-metabolizing enzymes (aniline hydroxylase and amidopyrine-N-demethylase) significantly. Histology demonstrated profound steatosis degeneration and nodule formation were observed in the hepatic architecture of carbon tetrachloride treated rats which were found to acquire near to normal in extract and TA with carbon tetrachloride administrated rats, and supported the biochemical observations. This study suggests that tannic acid has a more liver protective effect in comparison to extract of P. bistorta against carbon tetrachloride-induced hepatotoxicity and possess antioxidant activities.