Incidental Intracranial Findings and Their Clinical Impact; The HUNT MRI Study in a General Population of 1006 Participants between 50-66 Years (original) (raw)
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Acta Neurochirurgica
Background As the volume and fidelity of magnetic resonance imaging (MRI) of the brain increase, observation of incidental findings may also increase. We performed a systematic review and meta-analysis to determine the prevalence of various incidental findings. Methods PubMed/MEDLINE, EMBASE and SCOPUS were searched from inception to May 24, 2021. We identified 6536 citations and included 35 reports of 34 studies, comprising 40,777 participants. A meta-analysis of proportions was performed, and age-stratified estimates for each finding were derived from age-adjusted non-linear models. Results Vascular abnormalities were observed in 423/35,706 participants (9.1/1000 scans, 95%CI 5.2–14.2), ranging from 2/1000 scans (95%CI 0–7) in 1-year-olds to 16/1000 scans (95%CI 1–43) in 80-year-olds. Of these, 204/34,306 were aneurysms (3.1/1000 scans, 95%CI 1–6.3), which ranged from 0/1000 scans (95%CI 0–5) at 1 year of age to 6/1000 scans (95%CI 3–9) at 60 years. Neoplastic abnormalities were o...
Frontiers in Neurology, 2021
Background and Objectives: Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions of incidental findings (IFs) in this age group are scarce. We aimed to assess the prevalence and severity of IFs on brain MRIs of healthy young research participants aged 18–35 years, and to describe the protocol implemented to handle them. Methods: The study population comprised 1,867 participants aged 22.1 ± 2.3 years (72% women) from MRi-Share, the cross-sectional brain MRI substudy of the i-Share student cohort. IFs were flagged during the MRI quality control. We estimated the proportion of participants with IFs [any, requiring medical referral, potentially serious (PSIFs) as defined in the UK biobank]: overall, by type and severity of the final diagnosis, as well as the number of IFs. Results: 78/1,867 participants had at least one IF [4.2%, 95% Confidence Interval (CI) 3.4–5.2%]. IFs requiring medical referral (n = 38) were observ...
Journal of the neurological sciences, 2008
Background and purpose: Previous studies have addressed the prevalence of incidental findings largely in healthy adult and pediatric populations. Our study aims to elucidate the prevalence of incidental findings in a pediatric neurology practice. Methods: We reviewed the charts of 1618 patients seen at a pediatric neurology practice at a tertiary care center from September 2003 to December 2005 for clinical data and incidental intracranial findings on brain magnetic resonance imaging reports. Incidental findings were divided into two categories: normal or abnormal variants. Clinical and demographic data were assessed for associations with incidental findings. Results: From 1618 charts reviewed, only 666 patients (41% of all patients) had brain MRIs ordered. One-hundred and seventy-one (171) patients (25.7% of all patients; 95% CI: 22.6, 29.0) had incidental findings. Of these, 113 (17.0%; 95% CI: 14.1, 19.8) were classified as normal-variants and 58 (8.7%; 95% CI: 6.6, 10.9) were classified as abnormal. The nature of incidental findings was not related to age group, sex or clinical diagnosis (p = 0.29, p = 0.31 and p = 0.69 respectively). Two patients (0.3%; 95% CI: ∼ 0.0, 0.7) required neurosurgical referral. Conclusions: We report a high prevalence of and a low rate of referrals for incidental findings in comparison to previous studies. The present study may help guide management decisions and discussions with patients and families. Future studies should attempt to address issues of associations between primary or secondary diagnoses and intracranial incidental findings in a controlled, prospective fashion.
Incidental findings on brain magnetic resonance imaging
BMJ, 2009
Objective-Incidental findings identified by MRI of the brain have been reported in up to18% of healthy adults, with clinically significant neuropathology in 0.5-2%. There are two smaller series of incidental findings on MRI of the brain in children. We describe the prevalence and range of incidental intracranial abnormalities identified by MRI of the brain in a large group of children screened for a clinical trial.
Journal of Neurosurgery, 2014
Object It is assumed that the observed increase in brain tumor incidence may at least partially be explained by increased use of MRI. However, to date no direct estimate of this effect is available. The authors undertook this registry-based study to examine whether regional frequencies of cerebral MRI use correlate to regional incidence rates of intracranial tumors and survival of patients with these lesions. Methods The authors used Norwegian national population registries from January 2002 through December 2007 to conduct this observational study. They obtained information on outpatient MRI scans in Norwegian counties and examined whether the annual regional rates of cerebral MRI scans correlated to regional age- and sex-adjusted brain tumor incidence rates. They also explored whether differences in cerebral MRI use were associated with survival and examined time trends in the study period. Results Approximately 50,000 cerebral MRI scans are carried out annually in outpatient sett...
Incidental findings on brain MRI in the general population
New England Journal of Medicine, 2007
The contributions of the general practitioners and pharmacists of the Ommoord area to the Rotterdam Study are gratefully acknowledged. Financial support for publication of this thesis was kindly provided by / Financiële steun voor de publicatie van dit proefschrift werd mede verzorgd door Pfizer B.V., Janssen-Cilag B.V., Internationale Stichting Alzheimer Onderzoek, Glaxo Smith Kline, Stichting Het Remmert Adriaan Laan Fonds, Alzheimer Nederland, Erasmus MC, en Erasmus Universiteit Rotterdam. Cover design by Optima Grafische Communicatie, M.A. Ikram. Design and lay-out of thesis by Optima Grafische Communicatie, M.A. Ikram. Printed by Optima Grafische Communicatie.
Magnetic Resonance Imaging, 1990
Thirty-four patients with a wide variety of benign and malignant incidental skull findings on routine magnetic resonance (MR) imaging of the brain were reviewed. In most instances detection of the lesions was not difficult. However, recognition of various patterns of skull involvement in different disease processes is important. This is particularly true in differentiating benign from malignant lesions, which may he a critical factor in patient management.
Evaluation of common findings in brain computerized tomography (CT) scan: A single center study
Background: Computed Tomography (CT) is an invaluable imaging tool in the diagnostic workup of patients presenting with head trauma, stroke, brain tumour and epilepsy. The objective of this study was to document the common intracranial pathologies as revealed by CT in our setting and also determine if the indications for CT scan are justified so that patients are not exposed to radiation unnecessarily. Materials and methods: This was a cross-sectional study carried out in Hansa Clinic Enugu, Enugu State, Nigeria. Demographic data and brain CT radiological reports with imaging findings and clinical indications for patients referred to this study centre from January, 2017 to January 2019 were retrieved from the CT reports' archives and reviewed retrospectively. Relevant information such age, gender, radiological CT findings and clinical indications were collected using structured proforma. Results: A total of 300 patients' brain CT radiological reports were included in this study. The mean age of the patients was 41.25 ± 16.5 years with majority been within the age group of 31-40 years 92 (30.67%). Out of 300 cases, normal finding was highest 117 (39%) and the least was intracranial physiological calcification, which is 1 (0.33%). Headache is the most common clinical indication, 53 (17.67%) the least was unsteady Gait, which is 3 (1%). The Chi-square test revealed that there was statistically 312 AIMS Neuroscience Volume 7, Issue 3, 311-318. significance relationship between brain CT findings and clinical indications for the investigations (X 2 = 285.60, p = 0.002). Conclusion: The study showed that more males than females undergo brain CT scan with headache being the most common presenting complaint. The majority of findings of the brain CT scans in this study are normal despite, myriads of complaints necessitating the investigations. The study also revealed significant association between clinical indications and CT findings.
Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI)
Cephalalgia, 2015
Background Most studies on intracranial abnormalities among headache sufferers were performed in selected clinical populations. The aim of this study was to evaluate the relationship between intracranial abnormalities and headache among middle-aged adults in the general population. Methods Participants in a large epidemiological study (the HUNT 3 study; 2006–2008) who answered a headache questionnaire and participated in a population-based imaging study of the head (HUNT MRI; 2007–2009) were included ( n = 864; age, 50–65 at enrollment). Based on the responses to the HUNT 3 questionnaire, respondents were categorized as having migraine, tension-type headache, or unclassified headache. Logistic regression was used to compare the occurrence of intracranial abnormalities between groups. Results Intracranial abnormalities were more common in headache sufferers than in headache-free individuals (29% vs. 22%, respectively; p = 0.041). Adjusted multivariate analyses revealed that those wit...
Fifteen-minute consultation: incidental findings on brain and spine imaging
Archives of disease in childhood. Education and practice edition, 2014
Incidental findings on imaging of the brain and spine account for a large number of referrals to a paediatric neurosurgical practice. They can be cause of undue concern to the parents and can result in unnecessary investigations and interventions. This article is a review of the common pathological entities identified as incidental findings in the author's experience. The list is not exhaustive and reflects mainly the common conditions referred. Very few of these incidental findings would need surgical intervention.