Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children (original) (raw)
Related papers
There is evidence that oxygen free radicals play a vital part in the pathophysiology of numerous neuropsychiatric disorders. Although it has not been investigated yet, several recent studies proposed that nitric oxide (NO) and other parameters related to oxidative stress may have a pathophysiological role in autism. This study aims to evaluate the plasma levels of antioxidant enzyme, superoxide dismutase (SOD) and plasma level of Nitric oxide (NO), a marker of oxidative stress, in Egyptian autistic children. Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and pathology. The present study included 40 children with autism diagnosed by DSM-V-TR criteria and Childhood Autism Rating Scale. Controls included 40 age-matched healthy children. Cases were referred to Outpatient Clinic of Children with Special Needs Department, National Research Center, Cairo, Egypt. We compared levels of SOD, and NO in children with autism and controls. Level of NO was significantly higher in autistic children compared with their controls, while SOD was significantly lower among patients than controls. These findings indicate a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism. By /Shadia Abd El-Hamid 1, Naglaa Mostafa Sherif 1 , Nermine Ezz-eldine 2, 1 Biochemistry Department, Faculty of Science, Ain-Shams University, Egypt 2 Research on Children with special needs department, national research center, Egypt
Oxidative Stress Markers in Children with Autism Spectrum Disorders
Free Radical Biology and Medicine, 2012
This work was carried out in collaboration between all authors. Author MEGF was the principal investigator, designed the study, conducted the data analysis and wrote of the paper. Author M-LDH oversaw the laboratory measurements and performed the statistical analysis. Authors HV, CM and RG were the study neurologists, oversaw patient care and assisted with interpreting the results, Author EN classify the participants for the group control. Authors LB and MR assisted with interpreting the results. All authors read and approved the final manuscript.
A Prospective Study of Oxidative Stress Biomarkers in Autistic Disorders
E-Journal of Applied Psychology, 2009
The aim of this study was to evaluate oxidative stress (OS) biomarkers in a prospective, blinded cohort study of participants diagnosed with autism spectrum disorders (ASDs). OS biomarkers, including: blood glutathione (GSH), urine lipid peroxide, blood superoxidase dismutase (SOD), and blood GSH peroxidase (GPx) among participants diagnosed with ASDs (n=28) were evaluated in comparison to laboratory provided reference ranges. Testing was conducted using Genova Diagnostics (CLIA-approved). Participants diagnosed with ASDs had significantly (p<.005) decreased blood GSH and GPx relative to laboratory reference ranges. By contrast, participants diagnosed with ASDs had significantly (p<.000) increased urine lipid peroxide levels relative to laboratory reference ranges. A bimodal distribution of significant differences from the laboratory reference for blood SOD levels were observed (high=10.7%, low=14.3%). Finally, a significant (p=.05) inverse correlation was observed between blood GSH levels and ASD severity using Childhood Autism Rating Scale scores. The present observations are compatible with increased OS and a decreased detoxification capacity, particularly of mercury, in patients diagnosed with ASDs. Patients diagnosed with ASDs should be routinely tested to evaluate OS biomarkers and potential treatment protocols should be evaluated to potentially correct the OS abnormalities observed.
2005
a former primary care physician, treats ADHD and autism with nutritional interventions. Dr. McGinnis receives NIH funding and coordinates a multi-university oxidative stress in autism study. He is currently organizing an international oxidative stress in autism symposium scheduled for 2005. innoVision Comnuinications is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The learner should study the article and its figures or tables, if any, then complete the seltevaluntion al the end of the activit)'. The activit)' and self-evalualion are expected to take a maximum of 2 hours. STATEMENT OF PURPOSE Indirect markers are consistent with greater oxidative stress in autism. They include greater free-radical production. impaired energetics and cholinergics, and higher excitotoxic markers. Brain and gut. both abnormal in autism, are particularly sensitive to oxidative injury. Higher red-tell iipid peroxides and urinary isoprostanes in autism signify greater oxidative damage to biomolecules. A preliminary study found accelerated lipotuscin deposition-consistent with oxidative injury to autistic brain in cortical areas serving language and communication. Double-blind, placebo-controlled trials of potent antioxidants-vitamin C or carnosine-significantly improved autistic behavior. Benefits from these and other nutritional interventions may be due to reduction of oxidative stress. Understanding the role of oxidative stress may help illuminate the pathophysiology of autism, its environmental and genetic influences, new treatments, and prevention.
Variation of the REDOX Status in Patients with Primary Autism after Antioxidant Therapy
2017
Oxidative stress plays an important role in the pathophysiology of autism. This research was carried out to know if the indicators of oxidative stress improved after a diet and antioxidant treatment in patients with primary autism. We studied 40 cases with primary autism treated at the Clinical Genetics National Reference Service in Juan Manuel Márquez Pediatric Hospital and Mayabeque Neurodevelopment Consultation during October 2014 to June 2016. Markers of oxidative damage and antioxidant defense were determined. Patients with altered oxidative stress were treated with diet and antioxidant therapy and the response to treatment was re-evaluated over time. A high percentage of patients improved the results of protein oxidation products (p <0,001), and total peroxide values post-therapy. However malonylaldehyde results remained elevate after treatment. No significant results were found for the antioxidant defense markers. The results of this research suggest that the use of antiox...
Glutathione-Related Factors and Oxidative Stress in Autism, A Review
Autism spectrum disorders are complex neuro-developmental disorders whose neurobiology is proposed to be associated with oxidative stress which is induced by reactive oxygen species. The process of oxidative stress can be a target for therapeutic interventions. In this study, we aimed to review the role of oxidative stress, plasma glutathione (GSH), and related factors as the potential sources of damage to the brain as well as the possible related factors which reduce the oxidative stress. Methylation capacity, sulfates level, and the total glutathione level are decreased in autism. On the other hand, both oxidized glutathione and the ratio of oxidized to reduced glutathione are increased in autism. In addition, the activity of glutathione peroxidase, superoxide dismutase, and catalase, as a part of the antioxidative stress system are decreased. The current literature suggests an imbalance of oxidative and anti-oxidative stress systems in autism. Glutathione is involved in neuro-protection against oxidative stress and neuro-inflammation in autism by improving the anti-oxidative stress system. Decreasing the oxidative stress might be a potential treatment for autism.
Biological Trace Element Research, 2010
Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and pathology. This pilot study aims to evaluate the levels of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and levels of malondialdehyde (MDA), a marker of lipid peroxidation, in Egyptian autistic children. Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and pathology. The present study included 20 children with autism diagnosed by DSM-IV-TR criteria and Childhood Autism Rating Scale. Controls included 25 age-matched healthy children. Cases were referred to Outpatient Clinic of Children with Special Needs Department, National Research Center, Cairo, Egypt. We compared levels of SOD, GSH-Px, and MDA in children with autism and controls. In children less than 6 years of age, levels of SOD, and GSH-Px were significantly lower in autistic children compared with their controls, while MDA was significantly higher among patients than controls. In children older than 6 years, there was no significant difference in any of these values between cases and controls. We concluded that children with autism are more vulnerable to oxidative stress in the form of increased lipid peroxidation and deficient antioxidant defense mechanism especially at younger children. We highlight that autistic children might benefit from antioxidants supplementation coupled with polyunsaturated fatty acids. Moreover, early assessment of antioxidant status would have better prognosis as it may decrease the oxidative stress before inducing more irreversible brain damage.