An in vivo murine model of continuous intramedullary infusion of polyethylene particles (original) (raw)

Total joint replacement (TJR) is effective for improving mobility in osteoarthritic patients, yet wear debris causes complications like aseptic loosening and osteolysis. This study introduces an in vivo murine model for investigating continuous intramedullary infusion of polyethylene particles, simulating wear debris generation in TJR. Results indicate that polyethylene particle infusion increases osteoclast activity and alters bone structure, emphasizing the need to understand the biological effects of wear debris for developing longer-lasting orthopedic prostheses.