A neglected infection in literature: Childhood musculoskeletal tuberculosis - A bibliometric analysis of the most influential papers (original) (raw)
Related papers
National Journal of Community Medicine, 2024
"Background: Tuberculosis in children is highly prevalent and is considered community transmission by an infected adult. This study analyzed childhood tuberculosis literature from 2018 to 2023 on Scopus. Methodology: The study was an observational, retrospective design with a bibliometric approach focusing on the scientific production on childhood tuberculosis. A trend analysis and mapping of the literature published in Scopus was performed. The following selection criteria were applied: All types of papers published in Scopus during the study period were included. Papers published between 2018 and 2023 were included. Papers had to be focused on childhood tuberculosis. Results: Antoni Diez NogueraJulián from SJD Barcelona Children’s Hospital had a field-weighted citation impact of 10.89. Anneke Catharina Hesseling and James Alexander Seddon had the highest output. The University of Melbourne and the University of Barcelona had high field-weighted citation impacts. Despite the United States’ high production, Spain and Australia showed significant influence. The “International Journal of Tuberculosis and Lung Disease” led in production. Conclusions: A bibliometric study on childhood tuberculosis literature from 2018-2023 highlighted Antoni Diez Noguera-Julián’s significant citation impact and the high output of Anneke Catharina Hesseling and James Alexander Seddon. Despite the U.S.'s high production, Spain and Australia showed significant influence."
BMC Pulmonary Medicine, 2021
Purpose The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious clinical presentation. Methods A retrospective, descriptive study of the cases of Tuberculosis (TB) in children was carried out. A total of 159 cases met the condition for the analysis. Results The most frequent TB modality was extrapulmonary in 85%. Out of this, only 29% was OATB. The mean age was 4.9 years (range 8 months–16 years). Eighty-six per cent of cases received Bacille Calmette-Guérin (BCG) vaccination at birth. Median time of symptoms prior to diagnosis was 8 months. Microbiological confirmation was achieved only in five cases, with a high sensitivity to the antimicrobial treatment. Mycobacterium bovis BCG strain Tokio 172 was confirmed in three cases. Mortality rate was 0% during the tim...
Profile of osteoarticular tuberculosis in children
The Indian journal of tuberculosis, 2020
Objective: To determine clinical profile of osteoarticular tuberculosis (TB) in children. Methods: Cross-sectional analysis from 2007 to 2013. All patients diagnosed with bone TB, spinal TB or TB abscesses were included. Results: Out of 1318 children with TB, 39 (2.96%) had osteoarticular TB, of which 16 (42%) had osteomyelitis, 8 (20.5%) had spinal involvement, 7 (17.9%) had TB synovitis, 2 (5.1%) had psoas abscess and 6 (15.4%) had abscesses. The mean age of presentation was 7.1 ± 3.5 years (range 2e14 years). Of the 33 cases in which a culture was done, 25 (64%) showed a positive culture. Drug sensitivity tests were done in 21 patients of which 10 (47.6%) tested were drug resistant, of which 4 (36.4%) were multidrug resistant (MDR), 2 (18.2%) were extensively drug resistant (XDR), 3 were pre-XDR (27.3%) and 1 was polyresistant (9.1%). Nine (23.1%) patients had TB in the past with a treatment duration of 8.3 ± 5.3 months. Contact with a TB patient had occurred in 10 (25.6%) cases. Associated pulmonary TB were seen in 6 (15.39%) and TB meningitis were seen in 1 (2.6%) patients. Surgical intervention was needed in 11 (28.2%) patients of which 5 (45.5%) underwent curettage, drainage was done in 1 (9.1%), arthrotomy in 4 (36.4%) and spinal surgery in 1 (9.1%) patient. Conclusion: Drug resistant osteoarticular TB is an emerging problem in children.
Most Influential Literature in Spinal Tuberculosis: A Global Disease Without Global Evidence
Global Spine Journal
Study Design: Bibliometric review of the literature. Objective: This bibliometric analysis aims to give an overview of the most influential academic literature written on spinal tuberculosis. Methods: All databases included in the Thomson Reuters Web of Knowledge were searched for the most influential publications in spinal tuberculosis. The most cited articles published between 1950 and 2015, with the main focus on orthopedic surgery, were identified using a multistep approach, and a total of 100 articles were included. The publications were then analyzed in this bibliometric analysis. Results: The number of citations ranged from 243 to 36, with an average of 77.11. The articles were published in 34 different journals, and the studies were conducted in 20 different countries. The top 3 countries, India, the United States, and China, published a total of 51% (n ¼ 51) of all articles. Low-burden countries produced 60% (n ¼ 60) of all articles in our list. African centers produced only 4% (n ¼ 4) of all included articles. Conclusions: Indian and Chinese researchers dominate evidence in spinal tuberculosis. Other areas with high disease burden, such as Africa, do not feature. Most publications are retrospective studies with a low level of evidence.
Epidemiology of Musculoskeletal Tuberculosis in an Area with High Disease Prevalence
Asian spine journal, 2017
Retrospective observational study. The aim of this study was to assess the distribution of age and site of infection in patients with musculoskeletal tuberculosis (TB) and determine the number of TB/human immunodeficiency virus (HIV) coinfections as well as the incidence of multidrugresistant (MDR) TB. Of all TB cases, 1%-3% show skeletal system involvement and 30% are HIV coinfected. Although the reported distribution of skeletal TB is majorly in the spine, followed by the hip, knee, and foot/ankle, the epidemiology of extrapulmonary TB and especially musculoskeletal TB remains largely unknown, particularly in areas with a high prevalence of the disease. This is a retrospective study of a consecutive series of patients admitted to a tertiary care facility in an area with the highest prevalence of TB worldwide. TB was confirmed on tissue biopsy with polymerase chain reaction testing (Xpert for Mycobacterium tuberculosis and rifampicin resistance), culturing, or histological analysis...
2007
Tuberculosis appears to be increasing throughout the world after years of continuous decline, despite the introduction of effective chemotherapy. This resurgence is related to the increasing number of patients immunocompromised by chemotherapeutic agents used to treat other diseases or AIDS; the appearance of multiple drug-resistant strains of tuberculosis, and aging population. Several species of mycobacteria other than Mycobacterium tuberculosis or M. bovis are known to cause infections of bones and joints. The predisposing factors are malnutrition, environmental conditions and poor living standards. Musculoskeletal tuberculosis arises from haematogenous seeding of the bacilli soon after the initial pulmonary infection. The clinical symptoms are insidious onset, pain, swelling of the joint and limited range of movements. Investigations for suspected cases include: Mantoux test, radiological imaging, fine needle aspiration biopsy, surgical biopsy, bacteriological examination, histopathological examination, and polymerase chain reaction (PCR) of a suitable specimen. The mainstay of treatment is multidrug antitubercular chemotherapy. Surgical intervention is indicated in patients with abscess formation, intractable pain, neurological deficit, spine instability, kyphosis, and unsatisfactory response to chemotherapy. The main reason for poor outcome is delayed diagnosis.
Musculoskeletal Tuberculosis: Two Year Experience at a Tertiary Care Teaching Hospital of Northern India and Review of Literature, 2018
Background: The aim of this study was to evaluate the present trend of osteo-articular tuberculosis at a teaching hospital in North India. Methods: All the cases of skeletal tuberculosis that were diagnosed and managed either on outdoor or in-hospital stay basis over a period of two years were evaluated with respect to age, gender, anatomical location of lesion, laboratory parameters (ESR, Mantoux test, HIV screening), concomitant skeletal tuberculous lesions, associated pulmonary tuberculosis, and other associated clinical features. Results: A total of 84 skeletal tuberculous lesions in 80 patients were enrolled for the study. The age of the patients ranged from 2 to 70 years with a mean of 29.1±19.1 years. 55% patients were in second and third decade of life and 63.7% were males. ESR was elevated in 61.25% and 56.25% tested positive for Mantoux skin test. 21.25% patients had associated active or healed focus of tuberculosis in the lungs. Spine was the most common site involved (58.75%) followed by hip (13.1%), knee (8.3%), foot (4.7%) and shoulder joint (3.5%). Lumbar spine was the most common site affected in the spine followed by lower dorsal spine. 3.75% cases had multifocal skeletal tuberculous lesions. Conclusion: Prevalence of osteo-articular tuberculosis continues to be high in North India with the disease predominantly affecting young population. Spine is the most common site for skeletal tuberculosis followed by hip, knee, foot and shoulder. Lumbar region followed by lower dorsal spine is much more affected. Multifocal skeletal lesions incidence is lower than expected. And one-fifth of the patients have associated pulmonary tubercular lesion.
Tuberculosis in childhood: a systematic review of national and international guidelines
BMC Infectious Diseases, 2014
Background: Paediatric tuberculosis (TB) represents a major public health concern worldwide. About 1 million children aged less than 15 years develop TB each year, contributing to 3-25% of the total TB caseload. The aim of this review is to evaluate national and international guidelines concerning tuberculosis in childhood and compare them in terms of diagnosis and treatment strategies. Methods: A literature search of the Pubmed database was performed from January 2000 to August 2013, using the terms "tuberculosis" and "children". The search was limited to guidelines and consensus conferences, human species and full text availability, with no language restrictions.
Journal of Communicable Diseases
Background: The aim of this study was to evaluate the present trend of osteo-articular tuberculosis at a teaching hospital in North India. Methods: All the cases of skeletal tuberculosis that were diagnosed and managed either on outdoor or in-hospital stay basis over a period of two years were evaluated with respect to age, gender, anatomical location of lesion, laboratory parameters (ESR, Mantoux test, HIV screening), concomitant skeletal tuberculous lesions, associated pulmonary tuberculosis, and other associated clinical features. Results: A total of 84 skeletal tuberculous lesions in 80 patients were enrolled for the study. The age of the patients ranged from 2 to 70 years with a mean of 29.1±19.1 years. 55% patients were in second and third decade of life and 63.7% were males. ESR was elevated in 61.25% and 56.25% tested positive for Mantoux skin test. 21.25% patients had associated active or healed focus of tuberculosis in the lungs. Spine was the most common site involved (58.75%) followed by hip (13.1%), knee (8.3%), foot (4.7%) and shoulder joint (3.5%). Lumbar spine was the most common site affected in the spine followed by lower dorsal spine. 3.75% cases had multifocal skeletal tuberculous lesions. Conclusion: Prevalence of osteo-articular tuberculosis continues to be high in North India with the disease predominantly affecting young population. Spine is the most common site for skeletal tuberculosis followed by hip, knee, foot and shoulder. Lumbar region followed by lower dorsal spine is much more affected. Multifocal skeletal lesions incidence is lower than expected. And one-fifth of the patients have associated pulmonary tubercular lesion.
Consensus statement on childhood tuberculosis
Indian pediatrics
Justification: Revised National Tuberculosis Control Program (RNTCP) has focused on adults with smear positivity a tool not so well used in children with tuberculosis. There is a need to redefine standardization of diagnosis and management protocols for childhood tuberculosis. Process: Indian Academy of Pediatrics constituted a Working Group to develop consensus statement on childhood tuberculosis (TB). Members of the Group were given individual responsibilities to review the existing literature on different aspects of the childhood TB. The group deliberated and developed a consensus which was circulated to all the members for review. Efforts were made to ensure that the recommendations are standardized. Objectives: To produce recommendations and standard protocols for reasonably accurate diagnosis and rational treatment of tuberculosis in children. Recommendations: Fever and or cough > 2 weeks with loss of weight and recent contact with infectious case should arouse suspicion of...