Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma (original) (raw)

The observations that glucagon binds to glucagon-like peptide-1 (tGLP-1) receptors have raised the question of whether glucagon receptors mediate the insulinotropic effect of glucagon. This study investigates the presence and selective activation of glucagon and tGLP-1 receptors on tumor-derived hamster insulinoma cells. Both receptor types were found to exist with high affinity binding to their respective ligands, influencing cAMP formation, thus suggesting that glucagon and tGLP-1 have distinct insulinotropic effects mediated through their own specific receptors.