Adenosine A2A-Receptor Antagonism and Pathophysiology of Parkinson’s Disease and Drug-Induced Movement Disorders (original) (raw)
The A 2A receptors' role in the pathophysiology of Parkinson's disease and DIMDs is evidenced by the upregulation of A 2A receptors in patients with Parkinson's disease and patients receiving long-term administration of dopamine blockers. Further, A 2A-receptor antagonists are effective in reversing parkinsonian motor deficits and extrapyramidal symptoms in animal models of Parkinson's disease and DIMDs. Understanding the role of A 2A-receptor antagonism in the pathophysiology of Parkinson's disease and DIMD has therapeutic implications.
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