Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver (original) (raw)

Abstract

Abbreviations used in this paper: BSP, bromosulphophthalein; cRNA, complementary RNA; DHEAS, dehydroepiandrosterone sulfate; DPDPE, [D-penicillamine 2,5 ]enkephalin; E 2 17␤G, estradiol-17␤glucuronide; Lst-1/LST-1, rat/human liver-specific transporter 1; LTC 4 , leukotriene C 4 ; OAT-K1, rat kidney organic anion transporter; Oatp/ OATP, rat/human organic anion-transporting polypeptide; PCR, polymerase chain reaction; PGE 2 , prostaglandin E 2 ; Pgt/PGT, rat/human prostaglandin transporter; T 3 , triiodothyronine; T 4 , thyroxine.

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  32. Received July 31, 2000. Accepted September 11, 2000. Address requests for reprints to: Peter J. Meier-Abt, M.D., Division of Clinical Pharmacology and Toxicology, Department of Medicine, Uni- versity Hospital, CH-8091 Zurich, Switzerland. e-mail: meierabt@ kpt.unizh.ch; fax: (41) 1-255 4411. Supported by grants 32-59155.99 (to G.A.K.-U.), 31-59204.99 (to B.H.), and 31-045536.95 (to P.J.M.) from the Swiss National Science Foundation, Bern, Switzerland; grant KU 899/5-2 from the Deutsche Forschungsgemeinschaft, Bonn, Germany; and grant 99B30 from the Novartis Foundation for Biomedical Research, Basel, Switzerland.