Anti-hyperglycemic activity of Trichosanthes tricuspidata root extract (original) (raw)
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Antidiabetic activity of Trichosanthes cucumerina in normal and streptozotocin–induced diabetic rats
International Journal of Biological and Chemical Sciences, 2009
Aerial parts of Trichosanthes cucumerina (Family: Cucurbitaceae) are used in traditional medical systems for treatment of diabetes and other diseases. The present study was designed to experimentally evaluate the antidiabetic potential of a hot water extract (HWE) of T. cucumerina (TC) aerial parts. In normoglycemic rats, HWE mediated (a) a dose dependent reduction in fasting blood glucose (FBS) levels (by 35% at 4h post-treatment with dose of 750 mg/kg) and (b) a significant (P<0.05) improvement of glucose tolerance. In STZ-induced diabetic rats, no immediate hypoglycemic effect was observed. However, with continuous administration, there was a gradual reduction in FBS (by 56.8% on day 14 and by 64.4% on day 28). In normoglycemic rats, on day 14 and day 28, the percentage reduction in FBS levels were 41% and 44% respectively. At the end of 28 days, in both normoglycemic and STZ-induced diabetic rats, there was a significant increase in the levels of liver glycogen and adipose tissue triglyceride levels, in comparison with the respective controls that did not receive HWE. However, HWE failed to inhibit intestinal glucose uptake. It may be concluded that T.C can exert significant antidiabetic activity, possibly through multiple effects involving pancreatic and extra pancreatic mechanisms.
ISRN Pharmacology, 2013
The present study was undertaken to scientifically validate the antidiabetic activity of aqueous fruit extract of Trichosanthes dioica Roxb. (Family: Cucurbitaceae) which has been traditionally used for managing diabetes mellitus. This plant commonly known as “Sespadula” in English has not been explored scientifically so far for its glycemic potential except by our research group. The study was conducted with variable doses on normal, mild, and severe diabetics models, and several biochemical parameters including blood glucose level (BGL) were assessed. Maximum fall in BGL of 23.8% in normal rats and of 31.3% in mild diabetic rats was observed during their fasting blood glucose (FBG) and glucose tolerance test (GTT) with the dose of 1000 mg kg−1. In severely diabetic animals after 4 weeks treatment with FBG, postprandial glucose, total cholesterol, and triglyceride levels were reduced by 28.7, 30.7, 57.2, and 18.5%, whereas high density lipoprotein, total protein, hemoglobin, and bo...
Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats
Indian Journal of Clinical Biochemistry, 2008
In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD 50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.
International Journal of Biochemistry Research & Review, 2020
Aims: This study was designed to evaluate the antidiabetic effects of aqueous and ethanolic extracts of Trichilia emetica (TE) stem bark in albinos rats. Methodology: 24 rats of comparable weight were divided into 2 lots, including a control lot of 3 rats and a test lot of 21 rats. Diabetes was induced by injecting Alloxan® intraperitoneally (125 mg/kg bw) for 7 days. After the onset of diabetes, the animals were divided into several groups and given the extracts of Trichilia emetica and Diastabol® orally for 6 days according to the following protocol: Normal Control (NC) received normal saline, group diabetic control (DC) it consists of untreated diabetic, group DD10 and DD20 was comprised of diabetic animals treated with Diastabol® at a doses of 10 and 20 mg/kg bw respectively , group DTEE100 and DTEE200 it consists of diabetic animals treated with ethanolic extract at a doses of 100 and 200 mg/kg bw respectively, group DTEA100 and DDTEA 200 was comprised of diabetic animals tre...
Journal of Ethnopharmacology, 1997
The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonellafoenum-graecum leaf when given to both normal and alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed. On the other hand ethanolic extract of Trigonella foenum-graecum leaf produced no reduction in blood glucose concentration in normal rats but intra-peritoneal administration of 0.8 g/kg of the ethanolic leaf extract to diabetic rats produced a significant reduction of blood glucose concentration (p < 0.02) at 2 and 24 h only. Intraperitoneal and oral acute toxicity (LD50) and target organ effects were studied for the aqueous extract of Trigonella leaf in mice. LD50 of i.p. and oral administration were 1.9 and 10 g/kg respectively. The main organ affected after i.p. administration of the aqueous extract was the liver while oral administration of the aqueous extract of Trigonella did not produce any sign of organ damage. These results suggest that the aqueous extract of Trigonella foenum-graecum leaves given both orally and intraperit0neally possesses a hypoglycaemic effect in normoglycaemic and alloxan induced hyperglycaemic rats, © 1997 Elsevier Science Ireland Ltd.
Health science journal, 2021
Metabolic disorder diabetes results from an alteration of the secretion or action of insulin. Trigonella foenum-graecum is a traditionally used specimen since ancient times. We aimed to investigate the hypoglycemic potential of ethanolic extract of T. foenum-graecum seed powder solution both in a dose and source-dependent manner as well as to fathom out its safety profile so that this plant can be used to ameliorate diabetes. Diabetes was induced in the rat model via intraperitoneal injection of alloxan (150 mg/kg). Ethanolic extract of T. foenum-graecum was administered to rats’ belonged to different groups. Blood glucose levels were assessed periodically and the safety profiles were evaluated through assessment of SGOT, SGPT, creatinine, and lipid profiles after sacrificing the animals. It has been evidenced that T. foenum-graecum possesses anti-diabetic activity. Furthermore, the extract is capable of reversing the disturbed pathological state towards a healthy status. Besides, t...
Journal of Ethnopharmacology, 2002
The hypoglycemic effect of the aqueous (Aq) extract of the bark of Pterocarpus marsupium (PM) and alcoholic (Alc) extract of seeds of Trigonella foenum-graecum (FG) and leaves of Ocimum sanctum (OS) was investigated in both normal and alloxan-induced diabetic rats. The Aq extract of PM (1 g/kg PO) significantly (P B0.001) reduced the blood sugar levels from 72.32 9 5.62 to 61.3591.2 mg% 2 h after oral administration of the extract and also significantly lowered the blood glucose in alloxan diabetic rats from 202.91 95.44 to 85.22 911.28 mg% 21 days after daily oral administration of the extract (P B 0.001). Similarly, reduction was seen with Alc extract of FG (74.33 94.77 to 60.56 9 1.9 in normal rats and 201.25 9 7.69 to 121.25 9 6.25 in diabetic rats) (PB0.001) and OS (204.48 911.0 to 131.43 9 7.86 in normal rats and 73.54 9 3.7 to 61.44 9 2.3 in diabetic rats) (PB 0.001). In addition, the extract also showed a favorable effect on glucose disposition in glucose fed hyperglycemic rats.
The effects of ethanol extract of Trigonella foenum-graecum (Fenugreek) seeds on the blood glucose levels in alloxan-induced diabetic rats at different doses (2g/kg, 1g/kg, 0.5g/kg and 0.1g/kg) were studied. The hypoglycemic effect of extract was compared with that of the standard antidiabetic drug (glimepiride, 4mg/kg) single dose. The extract showed significant activity against the diabetic state induced by alloxan but the intensity of hypoglycemic effect varied from dose to dose. The most effective dose recognized was 1g/kg but that is still lower than the standard antidiabetic drug. No acute toxicity was observed for ethanol extract of T. foenum-graecum seed when it was administered orally at high dose level (3 g/kg body weight), which is higher than effective antihyperglycemic dose, and closely observed for 24 hrs for any mortality and next 10 days for any delayed toxic effects on gross behavioral activities. Phytochemical group tests were also accomplished and presence of alkaloids, steroids and carbohydrates were recognized in the extract.
Anti-Hyperglycemic and Lipid Lowering Activity of Trigonella foenum-graecum (Linn.) Leaves
Objective: Trigonella foenum-graecum (Linn.) (T foenum-graecum) belonging to family Fabaceae collected from southern Odisha was aimed to appraise the anti-hyperglycemic and lipid lowering activity of ethanolic leaf extract (200 and 400 mg/kg b.w.) by two different models for Antidiabetic activity screening viz. Alloxan induced and Streptozotocin-Nicotinamide (STZ-NA) induced diabetic models and Triton (WR 1339) induced hyperlipidemic model in rats. Method: The Antidiabetic activity of the extract was compared with standard drug Metformin (11.3 mg/kg of b.w.; p.o) and Gliclazide (25 mg/kg of b.w.; p.o) for Alloxan induced and Streptozotocin-Nicotinamide (STZ-NA) induced diabetic models respectively and Atorvastatin (7.2 mg/kg of b.w.; p.o) for Triton (WR 1339) induced hyperlipidemic model. The Blood glucose (GOD/POD method) and other biochemical parameters like total cholesterol, HDL cholesterol and triglyceride levels were estimated and very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol were calculated. Results: Treatment with T foenum graecum (400 mg/kg) to alloxan treated rats for 10 days significantly (p<0.001) attenuated the blood glucose level (141.30 ± 11.56 mg/dl) of test animals when compared to alloxan control (293.16 ± 7.32 mg/dl). Similarly, in STZ-NA induced diabetic model, significant (p<0.001) reduction in blood glucose level (152.61 ± 6.83 mg/dl) in test animals were observed, following the treatment of T foenum graecum (400 mg/kg) for 28 days. In Triton (WR 1339) induced hyperlipidemia (48 hour model), T foenum graecum (400 mg/kg) treatment exhibited significant (p<0.001) attenuation in serum total cholesterol (70.92 ± 3.46 mg/dl), triglyceride (125.67 ± 6.54 mg/dl) and LDL (10.42 ± 6.77 mg/dl) with significant (p<0.05) elevation in serum HDL (35.36 ± 5.32 mg/dl) levels. Statistical significance of data was assessed by One-way ANOVA followed with Tukey-Kramer Multiple comparison between different groups. The data obtained from the study suggested, the anti-diabetic and lipid lowering activities of T foenum graecum (Linn.) leaves.