Dibucaine interaction with phospholipid vesicles. A resonance energy-transfer study (original) (raw)

Uploaded (2021) | Journal: European Journal of Biochemistry

Abstract

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Resonance energy transfer between the local anesthetic dibucaine and various functionalized probes was utilized to explore the drug's location within phospholipid vesicles. It was determined that dibucaine intercalates near the glycerol backbone of the lipid membrane, with minimal influence from temperature variations. The research highlights the significance of dibucaine's charged form in membrane presence, contributing to understanding anesthetic action mechanisms.

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