Liver and serum iron: Discrete regulators of hepatic hepcidin expression (original) (raw)
Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2
Alessia Pagani
Haematologica, 2020
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Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin
Kostas Pantopoulos
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HJV and HFE Play Distinct Roles in Regulating Hepcidin
yunlong Tao
Antioxidants & Redox Signaling, 2015
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HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression
Xinggang Wu
Blood, 2014
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Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
Eleanor Ryan
Hepatology, 2010
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Slobodan Vukičević
Nature Genetics, 2009
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310 Impaired Bone Morphogenic Protein Signalling Underlies Hepcidin Deficiency in HFE Hereditary Haemochromatosis
Eleanor Ryan
Gastroenterology, 2010
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A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis
Pierre BRISSOT
Haematologica, 2009
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Common Variants in the BMP2, BMP4, and HJV Genes of the Hepcidin Regulation Pathway Modulate HFE Hemochromatosis Penetrance
Pierre BRISSOT
The American Journal of Human Genetics, 2007
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Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling
Edouard Charlebois
Blood, 2018
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Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
J. Truksa
Blood, 2009
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Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression
Caroline Enns
Cell Metabolism, 2009
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Iron-Dependent Regulation of Hepcidin in Hjv−/− Mice: Evidence That Hemojuvelin Is Dispensable for Sensing Body Iron Levels
John Wagner
PLoS ONE, 2014
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The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expression in Vivo
Caroline Enns
Journal of Biological Chemistry, 2010
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Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver
Caroline Enns
The Journal of biological chemistry, 2016
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Iron-Dependent Regulation of Hepcidin in Hjv2/2 Mice: Evidence That Hemojuvelin Is Dispensable for Sensing Body Iron Levels
Kostas Pantopoulos
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The hepcidin circuits act: Balancing iron and inflammation
Bryan Maliken
Hepatology, 2011
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Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane
Caroline Enns
Journal of Biological Chemistry, 2008
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Cis and trans regulation of hepcidin expression by upstream stimulatory factor
Henry Bayele
Blood, 2006
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Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis
Paolo Ventura
Gastroenterology, 2009
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Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
Caroline Enns
Blood, 2010
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Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression
An-Sheng Zhang
Journal of Biological Chemistry, 2009
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The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo
Caroline Enns
Communications Biology
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Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis
Alessia Pagani
Blood, 2007
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Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin
Kostas Pantopoulos
Hepatology, 2011
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Regulation of hepcidin in HepG2 and RINm5F cells
Thomas Herrmann
Peptides, 2007
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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
Richard Rodriguez
Hepatology, 2011
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Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse
Abdul Waheed
Blood Cells Molecules and Diseases, 2002
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Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
M. Muckenthaler, Lynne Montross
2003
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