Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations (original) (raw)

Understanding the longevity of β-lactam antibiotics involves examining the mechanisms of resistance, particularly the role of β-lactamases. This review focuses on the structural and mechanistic aspects of various classes of β-lactamases and their evolution as a response to the clinical usage of β-lactam antibiotics. It also highlights the importance of β-lactam antibiotic/β-lactamase inhibitor combinations in combating resistance, suggesting that insights from established β-lactam strategies can inform the development of future anti-infective therapies.