HIV protease as a target for retrovirus vector-mediated gene therapy (original) (raw)

Small-Molecule Inhibitors of HIV-1 Protease Dimerization Derived from Cross-Linked Interfacial Peptides

Michael Shultz

Angewandte Chemie International Edition, 2000

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Macromolecular Inhibitors of HIV-1 Protease CHARACTERIZATION OF DESIGNED HETERODIMERS

James Rozzelle

Journal of Biological Chemistry, 2000

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Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation

Charles Craik

Proceedings of the National Academy of Sciences, 1996

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An alternative strategy for inhibiting multidrug-resistant mutants of the dimeric HIV-1 protease by targeting the subunit interface

Michele Reboud-ravaux

Biochemical Society Transactions, 2007

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Toward the First Nonpeptidic Molecular Tong Inhibitor of Wild-Type and Mutated HIV-1 Protease Dimerization

Michele Reboud-ravaux

ChemMedChem, 2010

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Structure of the protease from simian immunodeficiency virus: Complex with an irreversible nonpeptide inhibitor

Charles Craik

Biochemistry, 1993

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Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease †

Yuan-fang Wang, Irene Weber

Journal of Medicinal Chemistry, 2007

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Yeast Two-Hybrid Assay for Examining Human Immunodeficiency Virus Protease Heterodimer Formation with Dominant-Negative Inhibitors and Multidrug-Resistant Variants

Charles Craik

Analytical Biochemistry, 2000

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Dimer Disruption and Monomer Sequestration by Alkyl Tripeptides Are Successful Strategies for Inhibiting Wild-Type and Multidrug-Resistant Mutated HIV-1 Proteases †

Regis Vanderesse

Biochemistry, 2009

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Conformationally constrained HIV-1 protease inhibitors

Joseph Vacca

Bioorganic & Medicinal Chemistry Letters, 1994

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Structural Basis of HIV-1 and HIV-2 Protease Inhibition by a Monoclonal Antibody

J. Lescar

Structure, 2001

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Discovery and optimization of nonpeptide HIV-1 protease inhibitors

John Domagala

Bioorganic & Medicinal Chemistry, 1996

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Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis

Miguel Fernandes

Chemical Biology & Drug Design, 2007

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Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742

Larry Klein

Antimicrobial Agents and Chemotherapy, 2008

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INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design 1

Alexander Wlodawer

Annual Review of Biophysics and Biomolecular Structure, 1998

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Human immunodeficiency virus protease inhibitors From drug design to clinical studies

Chiara Atzori

Advanced Drug Delivery Reviews, 1997

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Dimerization inhibitors of HIV1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes

Ana Felix

Antiviral Research, 2006

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Future appeal of comparative studies on putative binding sites of HIV-1 virus-encoded proteolytic enzyme inhibitor of different Food and Drug Administration-approved compounds

SAMI MELEBARI

HIV & AIDS Review

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New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

Celia Schiffer

Current Opinion in HIV and AIDS, 2008

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Inhibition of HIV by an anti-HIV protease synthetic peptide blocks an early step of viral replication

Jean-alain Fehrentz

Research in Virology, 1992

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Cyclic HIV protease inhibitors capable of displacing the active site structural water molecule

Bruce Aungst

Drug Discovery Today, 1997

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Molecular Recognition of Macrocyclic Peptidomimetic Inhibitors by HIV1 Protease † , ‡

David Fairlie

Biochemistry, 1999

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Small-Sized Human Immunodeficiency Virus Type1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S 2 ′ Pocket

Hamdy Abdel-Rahman

Journal of Medicinal Chemistry, 2009

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Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease

Bruce Torbett

Acta Crystallographica Section D Biological Crystallography, 2011

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An Orally Bioavailable HIV1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis

Sherin S. Abdel-Meguid

Biochemistry, 1994

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Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vitro

Masayuki Amano

Antimicrobial Agents and Chemotherapy, 2010

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1 Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed to be Robust against Drug Resistance

Visvaldas Kairys

2016

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GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro

Masayuki Amano

Antimicrobial Agents and Chemotherapy, 2013

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New HIV protease inhibitors for drug-resistant viruses

S. Rusconi

Therapy, 2006

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