Acylguanidines as small-molecule β-secretase inhibitors (original) (raw)

Journal of medicinal …, 2006

Abstract

Like other aspartic proteases, 20-23 BACE1 consists of two structural domains, the N-and C-terminus, which constitute the active site and a β-hairpin loop which forms the flap region. The flap opens to allow the substrate to enter and then closes down on the substrate ...

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