Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors (original) (raw)

Journal of medicinal …, 2009

Erik Wagner

Abstract

The identification of small molecule aminoimidazoles as potent and selective human β-secretase inhibitors is reported. These analogues demonstrate low nannomolar potency for BACE1 in a FRET assay, exhibit comparable activity in a cell-based (ELISA) assay, and show >100× ...

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