Psychophysiological interactions between caffeine and nicotine (original) (raw)

interactions between caffeine and nicotine PHARMACOL BIOCHEM BE-HAV 38(2) 333-337, 1991-The interactive effects of caffeine and mcotme were stud~ed m twelve subjects. Mood and phys~ologic responses to the pharmacologic components mcotme and caffeine were measured, whde controlhng for the sensory/behavioral aspects of smolong and coffee dnnkmg Two experimental sessions presented a caffeine × mcotlne design, with caffelnated or decaffemated coffee followed at thirty-minute intervals by controlled inhalations of mcotme and nonnlcotlne smoke Results showed that there was a s~gmficant interactive effect of caffeine and mcotme on subjective arousal such that mCOtlne decreased arousal only m the presence of caffeine These findings extend prewous work showing interactive effects of caffeine and self-tltrated doses of c~garette smoke m affecting subjective arousal The effects of mcotme on subjective arousal may, therefore, depend not only on mcotlne dose, but also on the presence of caffeine Heart rate was increased by mcotme and both systolic and dmstohc blood pressures were elevated by caffeine Caffeine also potentiated the increase m dmstohc blood pressure resulting from smoke mhalatlons, but th~s occurred irrespective of mCOtlne dose Nicotine Cigarette smoking Caffeme Coffee Arousal Car&ovascular