Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications (original) (raw)
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Effects of fish oil on serum lipids in men during a controlled feeding trial
The American journal of clinical nutrition, 1990
Effects of fish-oil (FO) feeding on serum lipids were investigated in a 42-d controlled diet study. Fifteen healthy male college students were assigned to one of three groups: control (0 g FO); 5 g FO, supplying 2 g n - 3 (omega-3) fatty acids (FAs); or 20 g FO, supplying 8 g n - 3 FAs. In an initial 7-d period subjects consumed a basal diet with no FO. Then FO replaced an equivalent amount of margarine for 5 wk. FO feeding significantly (p less than 0.05) decreased the serum n - 6 FAs, linoleic acid, eicosatrienoic acid, and arachidonic acid. A significant increase in the n - 3 FAs, eicosapentaenoic acid and docosahexaenoic acid, was noted in serum, platelet, and neutrophil phospholipids. The 20-g-FO group showed a 30% decrease (p less than 0.01) in triglycerides after 2 wk FO with no further decrease observed. Thus, 20 g FO produced changes in both FA patterns and triglyceride concentrations whereas 5 g FO produced changes in FA patterns only. Neither FO amount resulted in signifi...
Influence of fatty acids composition in different tissue of mice feeds with fish oils
Research, Society and Development, 2021
Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play an important role in human health. Fish oils enriched with EPA and DHA have commercialized in triacylglycerol (TAG) and ethyl ester forms (EE). In this study, we compared the impact of diets containing fish oil in ethyl ester and triacylglycerol forms as a lipid source in five different tissues as liver, skeleteral muscle, brain, and epididymal white adipose tissue (WAT). The DHA levels were higher in the WAT and skeletal muscle of TAG and EE groups in comparison with the SB group. The body weight and brain, liver, epididymal WAT, and gastrocnemius muscle weights, and serum glucose, TG, cholesterol were not different between the groups. Thus, we conclude that EPA and DHA in the form of EE or TAG influence the fatty acids composition of different tissues.
Aquaculture Research
This research aimed to evaluate the e¡ects of two dietary fat levels [low fat (LF) (10%), high fat (HF) (20%)] and sources [¢sh oil (FO), vegetable oil (VO)] on the growth and some physiological parameters of Caspian brown trout ¢ngerlings for 60 days. Tuna oil or blends of canola and soybean oils (85:15) were added to diets to design four feeds namely LFFO, HFFO, LFVO and HFVO according to the fat levels and sources. The ¢sh fed the LFFO diet had lower weight gain than the other ¢sh (Po0.05). The total n-6 fatty acids increased in ¢sh fed diets with the blends of VO, while the total n-3 fatty acids decreased in these ¢sh (Po0.05). Serum lysozyme activity was higher in ¢sh fed the HFVO diet than the other ¢sh (Po0.05). Serum glucose, total cholesterol, triglyceride and very low-density lipoprotein were lower in ¢sh fed LFFO than the other ¢sh (Po0.05). The present study demonstrates that in terms of ¢sh growth, VOs can be used as an alternate source of dietary fat, whereas ¢sh health and nutritional value are improved with the LFFO diet. According to these results, a partial substitution of FO by VO in high-level fat diets is suggested for long-term feeding of Caspian brown trout.
Why Fish Oil Fails: A Comprehensive 21st Century Lipids-Based Physiologic Analysis
Journal of Lipids, 2014
The medical community suffered three significant fish oil failures/setbacks in 2013. Claims that fish oil's EPA/DHA would stop the progression of heart disease were crushed when The Risk and Prevention Study Collaborative Group (Italy) released a conclusive negative finding regarding fish oil for those patients with high risk factors but no previous myocardial infarction. Fish oil failed in all measures of CVD prevention-both primary and secondary. Another major 2013 setback occurred when fish oil's DHA was shown to significantly increase prostate cancer in men, in particular, high-grade prostate cancer, in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) analysis by Brasky et al. Another monumental failure occurred in 2013 whereby fish oil's EPA/DHA failed to improve macular degeneration. In 2010, fish oil's EPA/DHA failed to help Alzheimer's victims, even those with low DHA levels. These are by no means isolated failures. The promise of fish oil and its so-called active ingredients EPA / DHA fails time and time again in clinical trials. This lipids-based physiologic review will explain precisely why there should have never been expectation for success. This review will focus on underpublicized lipid science with a focus on physiology.
European journal of …, 2008
Cardiovascular disease still remains as one of the leading causes of disability and mortality. Epidemiological and clinical studies have reported a beneficial effect of both a-linolenic acid (ALA, 18:3n-3) and eicosapentaenoic acid (EPA, 20:5n-3)/docosahexaenoic acid (DHA, 22:6n-3) on the cardiovascular system [12, 23] through improvements in blood lipid profile [7, 27], decreasing blood pressure [18], and reducing inflammatory proteins (IL-1b, IL-6, TNF-a, IL-12, and interferon-d) [14, 16, 25, 43]. The largest dietary source of ALA is flaxseed oil, while marine products are the main natural sources of EPA/DHA. Majority of research to date has focused on EPA/DHA on cardiovascular health, while limited studies on ALA benefits are available. Also, the majority of these studies have involved supplementation of n-3 fatty acids (FA), without fully controlling for background diet.
The Journal of nutrition, 2008
Both (n-3) long-chain PUFA (LCPUFA) and linoleic acid [LA, 18:2(n-6)] improve cardiovascular disease (CVD) risk factors, but a high-LA intake may weaken the effect of (n-3) LCPUFA. In a controlled, double-blind, 2 x 2-factorial 8-wk intervention, we investigated whether fish oil combined with a high- or low-LA intake affects overall CVD risk profile. Healthy men (n = 64) were randomized to 5 mL/d fish oil capsules (FO) [mean intake 3.1 g/d (n-3) LCPUFA] or olive oil capsules (control) and to oils and spreads with either a high (S/B) or a low (R/K) LA content, resulting in a 7.3 g/d higher LA intake in the S/B groups than in the R/K groups. Diet, (n-3) LCPUFA in peripheral blood mononuclear cells, blood pressure (BP), heart rate (HR), and plasma CVD risk markers were measured before and after the intervention. FO lowered fasting plasma triacylglycerol (TAG) (P < 0.001) by 51% and 19% in the FO+R/K-group and FO+S/B-group, respectively, which was also reflected in postprandial TAG m...
Effects of ω-3 fatty acids and ratio of ω-3/ω-6 for health promotion and disease prevention
Food Science and Technology, 2022
Awareness of the role of essential fatty acids in human health and disease prevention has been increasing among the population over the past decades. It is known that the positive correlation of essential fatty acid content with a decrease in cardiovascular morbidity and mortality, infant development, brain and vision functioning, arthritis, hypertension, diabetes mellitus, and neurological/neuropsychiatric disorders. Rich sources of essential fatty acids are fish, fish oil, and some vegetable oils. In this paper, the average content of linoleic and α-linolenic acids in oils (g/100 g of fat) and their ratio is presented. In Kazakhstan, among vegetable oils, sunflower oil is the most commonly consumed, in which the ratio ω-6 to ω-3 on average is about 220:1, which exceeds all recommended norms. Based on the examination of literary data on this topic, the desk-based research approach was used in this paper. According to the results, statistical data on the number of diseases of the cardiovascular system and diabetes mellitus are confirmed by studies on the positive relationship between PUWC and the development of these diseases, which indicates the need to conduct more studies on the ratio of ω-6 to ω-3 in the diets. The objective of this research is to encourage scientists to increase their basic grasp of biochemistry in order to improve health and prevent fatty acid illness.
Lipids, 2007
A 20-week feeding trial was conducted to determine whether increasing linolenic acid (18:3n-3) in vegetable oil (VO) based diets would lead to increased tissue deposition of 22:6n-3 in Nile tilapia (Oreochromis niloticus). Five isonitrogenous and isoenergetic diets were supplemented with 3% of either linseed oil (LO), a mixture of linseed oil with refined palm olein oil (PO) (LO-PO 2:1) and a mixture of refined palm olein oil with linseed oil (PO-LO 3:2) or with fish oil (FO) or corn oil (CO) as controls. The PO-LO, LO-PO and LO diets supplied a similar amount of 18:2n-6 (0.5% of diet by dry weight) and 0.5, 0.7 and 1.1% of 18:3n-3, respectively. Increased dietary 18:3n-3 caused commensurate increases in longerchain n-3 PUFA and decreases in longer-chain n-6 PUFA in the muscle lipids of tilapia. However, the biosynthetic activities of fish fed the LO-based diets were not sufficient to raise the tissue concentrations of 20:5n-3, 22:5n-3 and 22:6n-3 to those of fish fed FO. The study suggests that tilapia (O. niloticus) has a limited capacity to synthesise 20:5n-3 and 22:6n-3 from dietary 18:3n-3. The replacement of FO in the diet of farmed tilapia with vegetable oils could therefore lower tissue concentrations of 20:5n-3 and 22:6n-3, and consequently produce an aquaculture product of lower lipid nutritional value for the consumer.