Myoepithelioma of the Soft Palate: a Case Report Giving Special Attention to the Differential Diagnosis (original) (raw)
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Myoepithelioma of hard palate: A case report
Journal of Medicine, Radiology, Pathology & Surgery, 2017
Myoepitheliomas (ME) are benign neoplasm originating from myoepithelial cells of seromucinous glands. Majority of these tumours arise in parotid gland followed by minor salivary glands of palate. The tumor does not show any unique clinicopathologic features that is different from other benign salivary gland tumors but is believed to have more aggressive behaviour. The histopathological patterns vary to very great extent and usually show overlapping features with other benign and malignant tumours. We report a case of 38-year-old male patient with a solitary swelling present on the right side of the hard palate. The histopathologic picture of the lesion showed spindle, plamacytoid and epitheliod cells. The connective stroma showed areas of hyalinization and keratin pearl formation making it difficult to differentiate from pleomorphic adenoma as well as its malignant counterpart. An Immunohistochemical analysis was done using S100, smooth muscle actin, Ki-67 and a definitive diagnosis of ME was made.
Malignant Myoepithelioma of Palate – A case report
Medico-Legal Update, 2011
A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence. Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman. The lesion had been examined by biopsy at another hospital, and diagnosed as a poorly differentiated squamous cell carcinoma. The patient underwent a wide local tumor resection. Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma. Five months after the operation, the patient was well without evidence of recurrence or metastasis.
Yonsei Medical Journal, 2009
A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence. Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman. The lesion had been examined by biopsy at another hospital, and diagnosed as a poorly differentiated squamous cell carcinoma. The patient underwent a wide local tumor resection. Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma. Five months after the operation, the patient was well without evidence of recurrence or metastasis.
Journal of Oral Medicine and Oral Surgery
Introduction: Myoepithelioma (ME) is a rare salivary gland tumor. Constructed aroung a clinical case, this article aims to gather up up-to-date epidemiological, clinical and histological data about myoeptihelioma with emphasis on the diagnostic approach and differential diagnoses, paraclinical exams and the main histological features reported for its characterization. Observation: A 41-year-old female, presenting a 1-year slowly enlarging palatine nodule was referred to the Oral Pathology Consultation. Clinical data and paraclinic examination were non-specific. A thorough histological examination, comparing clinical data with cyto-architectural and immunostaining profile of the tumor allowed a positive diagnosis of ME. Discussion: The clinical aspect of ME is close from other more frequent tumors within the same areas. Accordingly, its discovery is often incidental and its diagnosis histological. ME display variable architecture and composition, requiring full tumor examination for ...
Journal of Oral and Maxillofacial Pathology, 2013
Myoepitheliomas are rare, benign neoplasms affecting predominantly parotid gland and to a lesser extent minor salivary glands. In this article we have reported three cases with different histomorphological patterns. Two cases are from oral cavity and one from sinonasal tract, a very rare location. We have discussed different histomorphological patterns of myoepitheliomas, which at times possesses a real diagnostic dilemma to a pathologist. Along with its morphology, immunohistochemical profile and clinical behavior are discussed in detail with relevant review of literature.
Malignant myoepithelioma of palate
Contemporary Clinical Dentistry, 2012
Malignant myoepithelioma is a rare salivary gland neoplasm, which accounts for less than 2% of all the salivary gland carcinomas. Majority of cases have been reported in parotid, and only 8 cases of involvement of the hard palate have been reported in the literature so far. Hereby, a case of painless, ulcerated palatal mass of 2 years of duration reported. A diagnosis of malignant plasmacytoid myoepithelioma was made with the aid of immunohistochemical analysis, and wide surgical excision was considered keeping in mind the biological behavior of the tumor.
Myoepithlioma of Soft Palate: a case report
Journal of College of Medical Sciences-Nepal
Myoepithelioms are rare benign salivary gland tumors representing 1–1.5% of all salivary gland tumors. It was once considered to be one end of the histologic spectrum of pleomorphic adenoma (PA), but myoepitheliomas today are believed to be distinct entity. Herein we report a case of myoepithelioma in a 49 years old female patient with the history of swelling in the soft and hard palate. The diagnosis was made on the basis of histopathological findings and immunohistochemical report.
Misinterpreted Myoepithelial Carcinoma of Salivary Gland
American Journal of Surgical Pathology, 2019
Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). All MECAs ex-PA were intracapsular or minimally invasive except for 3 cases. Eighteen (86%) were initially misinterpreted as benign neoplasms, including PA (10), atypical PA (5), and myoepithelioma (3). The remaining 3 were initially diagnosed as malignant (MECA ex-PA) but were histologically challenging. Histologic features that were found most helpful in recognizing the malignant nature of MECA included: uniformly cellular myoepithelial proliferation with an expansile nodular lobulated pattern (all cases) and alternate hypocellular and hypercellular zonal distribution (76% of cases). Among the 16 MECA patients with follow-up, 14...
Myoepithelioma of a minor salivary gland of the cheek: case report
Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale, 2006
Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. The histological appearance includes solid, myxoid and reticular growth patterns. Vimentin and S-100 protein are very sensitive but non-specific immunohistochemical markers of neoplastic myoepithelium. Conservative surgery is the treatment of choice. A case of myoepithelioma of the minor salivary gland of the cheek with low grade malignancy is described, focusing on clinical behaviour, histopathological and immunohistochemical features and differential diagnosis.
Clear cell malignant myoepithelioma of the salivary glands
Histopathology, 1996
Clear cell malignant myoepithelioma of the salivary glands Previous reports of monomorphic clear cell carcinoma of the salivary glands have shown inconsistent results with immunohistochemistry, especially for S-100 protein, and this has led to uncertainty about the nature of these tumours. We believe that much can be explained by considering this group as comprising not one but two separate neoplasms, one epithelial and the other myoepithelial. The former has been described as hyalinizing clear cell carcinoma-it generally occurs in the minor salivary glands, and strongly expresses cytokeratins but not S-100 protein or ® smooth muscle actin. In contrast, this study presents five primary malignant tumours of the major salivary glands also composed largely of a single population of clear cells, but displaying histological and immunohistochemical features of myoepithelial differentiation, such as the formation of collagenous spherules and expression of S-100 protein and actin. A small number of similar tumours have been reported previously. We, therefore, believe that these neoplasms represent a clear cell variant of malignant myoepithelioma (myoepithelial carcinoma).