A rare case of ectopic adrenal tissue in the left ovary in a patient with a granulosa-cell tumor of the right ovary (original) (raw)
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Ovarian serous cystadenoma with ectopic adrenal tissue in a 65-year-old patient: A case report
International Journal of Surgery Case Reports, 2017
INTRODUCTION: Ectopic adrenal tissue is a very rare entity in adult females, especially in the ovary, and is generally diagnosed incidentally during surgery. Although it can present at various sites during childhood, it becomes atrophic by adulthood due to normally functioning adrenal glands. Patients are predominantly asymptomatic; however, in some cases endocrine symptoms such as hypertension and fasciotruncal obesity due to hormonal activity can be seen or neoplastic transformation can appear. PRESENTATION OF CASE: A 65-year-old patient with progressive pelvic pain and postmenopausal vaginal bleeding was evaluated by transvaginal ultrasound, which revealed bilateral adnexal masses measuring 5 cm in size and a normal uterus with an increased endometrial thickness of 7 mm. Initially the endometrial sampling result was reported as benign. The patient underwent abdominal hysterectomy and bilateral salpingo-oophorectomy and the pathological diagnosis was again benign, with serous ovarian cystadenoma being found in both ovaries. The pathologist also reported incidental ectopic adrenal tissue on the wall of the left ovarian cystadenoma. DISCUSSION: Ectopic adrenal tissue is infrequent in female genital organs especially at older ages. Only a few cases of ovarian ectopic adrenal tissue have been reported. To the best of our knowledge the present case is the fourth report in the English literature, and is of additional importance given the patient's age. CONCLUSION: Ectopic adrenal tissues are generally asymptomatic and revealed incidentally during surgery; however some cases have demonstrated the risk of neoplastic transformation. Therefore, surgeons must be aware of this rare entity that bears the risk of malignancy, and should surgically remove all suspicious lesions.
Clinicopathological Evaluation of 15 Ectopic Adrenal Tissues
Archives of Iranian medicine, 2021
BACKGROUND Ectopic adrenal tissue is a rare condition associated with embryological development defects seen in many different areas in the abdomen and pelvis. Here, we aimed to discuss the clinicopathological features of ectopic adrenal tissues diagnosed in our clinic, in light of the literature. METHODS We included cases of ectopic adrenal tissues incidentally detected in the specimens from patients undergoing operation for various diagnoses during 2012- March 2020. The cases were examined according to gender, age, location and accompanying pathological diagnoses. During this period, 15 cases of ectopic adrenal tissues (6 paratubal, 3 paraovarian, 2 paratesticular, 1 spermatic cord, 1 paraaortic, 1 liver capsule, 1 omentum) were detected accompanied by two endometrial carcinomas, two serous cystadenomas, one seminoma, one mixed germ cell tumor, one bilateral ovarian serous carcinoma and hepatic high-grade colon adenocarcinoma metastasis. RESULTS In this report, the fifth ectopic a...
Hormone Molecular Biology and Clinical Investigation
Ectopic adrenal tissue in the ovary is a rare entity. We reported a case of ectopic adrenal tissue in borderline mucinous cystadenoma of the left ovary. A 22 year-old student presented with progressive abdomen distension associated with discomfort for 3 months. Imaging investigation was suggestive of mucinous left ovarian cyst. Left salpingo-oophorectomy was performed and the histopathology revealed borderline mucinous cystadenoma with an incidental finding of ectopic adrenal tissue. This is an interesting case because of its rarity and potential risk of neoplasm changes.
Adult Granulosa Cell Tumor of Ovary: Clinical Study of 10 Cases
Indian Journal of Gynecologic Oncology, 2019
Purpose To evaluate the clinicopathological entities of adult granulosa cell tumor of ovary. Method A retrospective analysis of ten cases of adult granulosa cell tumor of ovary managed in a tertiary care center (VPS Lakeshore hospital, Kochi) from 2004 to 2018. Results Ten cases were identified to have adult granulosa cell tumor (GCT). Mean age was 45.3 years (range 31-63 years). Irregular cycles, palpable mass and pain abdomen were presenting complains. Palpable abdomino-pelvic mass was present in 7 (70%). Only one case had preoperative rise in serum Ca125 level. Serum inhibin analysis was done in postoperative period only, and one case had raised inhibin. Out of ten cases, 6 underwent laparoscopic surgery for adnexal mass and diagnosis of GCT was made in the final histopathology report. Five of them underwent completion surgery later on. Adjuvant chemotherapy was given in three of the cases. Total of 7 cases (70%) had recurrence. Pelvis was common site of recurrence, and mean duration of recurrence was 5.08 years (24-132 months). Mean disease-free period was 3.97 years (6-132 months). There were four mortalities. The longest follow-up duration for single case till the date was 13 years with recurrence in between. Conclusion Granulosa cell tumor of ovary is rare form of ovarian malignancy. Stage is the important prognostic factor. It has good prognosis compared to epithelial ovarian neoplasm. It is difficult to predict preoperatively. Care should be taken to prevent spillage while dealing with adnexal mass which occurs commonly in minimal access surgery and minilaparotomy.
Virilising ovarian tumour in a woman with an adrenal nodule
Case Reports, 2010
BACKGROUND Androgen secreting tumours are generally associated with rapidly progressive symptoms of hyperandrogenism resulting in virilisation. They are the least common of the androgen excess disorders, having a prevalence of 0.2%. 1 2 These tumours may arise from the adrenal glands or the ovaries. Androblastomas of the ovary may present as
Granulosa Cell Tumors of the Ovary: A Retrospective Tertiary Center Experience
Journal of clinical obstetrics & gynecology, 2021
Granulosa cell tumor (GCT) is a rare ovarian malignancy originating from sex cord-stromal cells. Sex cord stromal tumors account for 5-8% of all ovarian malignancies. 1 GCTs, which constitute approximately 70% of sex cord stromal ovarian tumors, are seen in 0.4-1.7 per 100,000 women. They are divided into 2 subgroups as juvenile (5%) and adult (95%) tumors based on their clinical presentation and histologic characteristics. The only clinically proven prognostic factor regarding recurrence is stage. However, patient age, tumor size, presence of intraperitoneal disease and the scope of the operation also play a role in prognosis. 2 Histological prognostic factors include nuclear atypia and mitosis. 3 Average recurrence is 5 years after surgery for the primary tumor. However, cases recurring even 20-30 years after the initial diagnosis have been reported in the literature. 4 Only 2% of GCT cases are bilateral, and most cases are diagnosed at Stage 1. Synchronous GCT has also been reported very rarely. They are usually lowgrade tumors with good prognosis. The most common presentation includes abdominal pain and distention. 5 Also they can secrete estrogen. Endometrial thickness should be evaluated with transvaginal ultrasound