Evidence That GnRH Decreases with Gonadal Steroid Feedback but Increases with Age in Postmenopausal Women (original) (raw)

Abstract

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This research investigates the effects of gonadal steroid feedback and aging on GnRH levels in postmenopausal women. The study demonstrates that with the decline of gonadal function after menopause, there is an increase in LH and FSH due to the loss of ovarian steroid negative feedback. Interestingly, the findings reveal that while gonadal feedback decreases GnRH levels, aging in postmenopausal women is associated with an unexpected increase in GnRH secretion. The study employs a competitive GnRH antagonist methodology to derive a semiquantitative estimate of GnRH secretion, highlighting the complex interplay between feedback mechanisms and age-related changes in hypothalamic function.

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  48. Second Transplant Bone Disease Meeting (TBDM 2002) [satellite of the XIX International Congress of the Transplantation Society] Buenos Aires, Argentina August 16 -17, 2002
  49. For further information, please contact Program Chair Dr. Luisa Plantalech, Tinogasta 2560 1°19 (C1417EHD), Buenos Aires, Argentina. E-mail: transbone@ciudad.com.ar; Web site: www.tbdm2002.com.