İzole Ön Kol Tekniği Kullanımında Farklı Rokuronyum Konsantrasyonlarının Enjeksiyon Ağrısı ve Hemodinami Üzerine Etkilerinin Karşılaştırılması (original) (raw)

2013, Turkish Journal of Anesthesia and Reanimation

Introduction R ocuronium is a steroidal nondepolarizing neuromuscular blocking agent, with similar block onset time as succinylcholine, which is preferred by the anaesthetists because of its rapid effect (1). One of the most frequent complications of rocuronium is injection pain. Even after anaesthesia induction when a state of complete hypnosis is achieved, this pain may lead to hand withdrawal (1-3). The mechanism of pain is not completely known. In order to prevent this side effect, premedication with various drugs before rocuronium injection and application of rocuronium together with drugs such as lidocaine, midazolam and fentanyl had been tested (3-6). Multiple studies evaluated rocuronium-associated pain and hand withdrawal (2, 3, 6). In our study, using isolated forearm technique, we aimed to evaluate the effects of three different concentrations (10 mg mL-1 , 5 mg mL-1 , 2.5 mg mL-1) of rocuronium on pain, rash, and skin eruptions and the hemodynamic changes associated with this complication. Methods After the approval of the Ethics Committee of İstanbul University Cerrahpaşa Medical School (approval date 03.05.2011 and number 28234), a randomized clinical, prospective, double-blind study was performed in the General Surgery operating theatre, on 80 ASA I-II patients who required general anaesthesia. The study was performed after obtaining the informed consent of the patients. Exclusion criteria were, known allergies to any anaesthetic agent, dementia, the presence of diseases causing tremor or involuntary movements such as Alzheimers' or Parkinsons' disease and being younger than 18 years of age. Before injection, the patients were informed that the medication used might cause burning sensation in hands. Patients were informed on the Visual Analogue Scale (VAS), and after the drug was administered, they were asked to evaluate pain intensity on VAS. VAS is a horizontal or vertical 10 cm line; anchored by "No Pain" at one end and "Unbearable Pain" at the other. At the same time with patients VAS evaluation, a numeric scale which was produced to evaluate it numerically (7-9).