On the phase space structure of IP3induced Ca2+signalling and concepts for predictive modeling (original) (raw)

The paper explores the phase space structure of IP3-induced Ca2+ signaling, emphasizing the correspondence between mathematical frameworks and biological systems. It examines the dynamics of Ca2+ signaling across various cell types and discusses how stochastic variables and phase space structure influence model predictions. Key features include the identification of a reaction-diffusion system that captures the general properties of Ca2+ dynamics, the descriptive role of spiking regimes in the context of noisy excitability, and the derivation of simplified models for predictive insights into cellular signaling.