Erratum to: Resveratrol and red wine, healthy heart and longevity (original) (raw)
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Resveratrol and red wine, healthy heart and longevity
Heart Failure Reviews, 2010
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
Free Radical Biology and Medicine, 2009
Resveratrol increases longevity through SirT1, which is activated with NAD + supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine N resveratrol N tyrosol N hydroxytyrosol N red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol N red wine N hydroxytyrosol N white wine N tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
Free Radical Biology Medicine, 2009
Resveratrol increases longevity through SirT1, which is activated with NAD + supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine N resveratrol N tyrosol N hydroxytyrosol N red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol N red wine N hydroxytyrosol N white wine N tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen
2006
Epidemiological studies demonstrated that even in the absence of other risk factors (e.g. diabetes, hypertension, hyperhomocysteinemia, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by enhancing vascular oxidative stress and inflammation. Because the population in the Western world is rapidly aging, there is a substantial need for pharmacological interventions that delay the functional decline of the cardiovascular system. Resveratrol is an atoxic phytoestrogen found in more than 70 plants including grapevine and berries. Recent data suggest that nutritional intake of resveratrol and other polyphenol compounds may contribute to the "French paradox", the unexpectedly low cardiovascular morbidity in the Mediterranean population. There is increasing evidence that resveratrol exerts multifaceted antioxidant and/or anti-inflammatory effects in various disease models. Importantly, resveratrol was reported to slow aging and increase lifespan in simple organisms and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reported to activate NAD-dependent histone deacetylases (sirtuins), which may contribute to its anti-aging effects. This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds.
The role of resveratrol in cellular aging
2019
Resveratrol is a substance present in grapes, blueberries and peanuts. Its concentration in grapes varies depending on the type and strain of the fruit. Resveratrol has a number of health-promoting properties for the body. Researchers most often indicate antioxidant, anticancer and cardioprotective activity, especially in the context of coronary heart disease, as well as anti-inflammatory, inhibiting the proliferation of pro-inflammatory cytokines. Resveratrol plays a neuroprotective role in the body, especially in the context of Alzheimer's disease, has a positive effect on the genes responsible for longevity and is the perpetrator of the so-called "The French paradox". The aim of the work was to present the role of resveratrol in cellular aging.
Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases
Oxidative Medicine and Cellular Longevity, 2021
The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.
2012
Objective: To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to w0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background: Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods: Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results: Expressions of p53 decreased w50% wwith RW and LRS (p < 0.05 vs. C), p16 by w29% with RW (p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 AE 1.2, RW 38.7 AE 1.7, LRS 38.5 AE 1.6, HRS 38.3 AE 1.8 mlO 2 min À1 kg À1 ), and RW or LRS also improved time of exercise tolerance vs. C (p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C ¼ 673 AE 30 days, p ¼ NS. Conclusions: RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.
Resveratrol in prevention and treatment of common clinical conditions of aging
Clinical interventions in aging, 2008
Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer's disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly a...
Free Radical Research, 2019
Mediterranean diet (MD) is the most relevant nutritional aspect of the multi-secular Mediterranean civilization which includes wine as an element of health and wellbeing when consumed with moderation. Mediterranean meals provide food micronutrients which include polyphenols, especially resveratrol from grape and red wine. MD, also called Cretan diet, has been proven to prevent diseases including cardiovascular pathologies, cancer, and to prevent aging. Interestingly, the grape and more precisely in grape skin contains the highest concentration of RSV. In consequence, red wine it is the most concentrated food source of RSV found in human diet. This review topic deals to how efficient is RSV towards alterations during the aging process; obtained from recent data of clinical trials, pre-clinical studies and cell culture approach; expecially RSV protecting effect on brain aging of elderly; its role on the microglial cells playing a central role in the neuro-inflammation; and in its anti-inflammatory effects on ocular diseases.