EBV and HIV-Related Lymphoma (original) (raw)

HIV-associated lymphoproliferative disorders represent a heterogeneous group of diseases, arising in the presence of HIV of HIV-associated lymphoma is significantly higher c population and it continues to be relevant even after the wide availability of highly active antiretroviral therapy (HAART) (1). Moreover, they still represent one of the most frequent cause of death in HIV-infected patients. involved in human lymphomagenesis, particularly in HIV immunocompromised patients. It has been largely implicated in the development of B Burkitt lymphoma (BL), Hodgkin primary central nervous system lymphoma (PCNSL), nasopharyngeal carcinoma (NC). Virus-associated lymphomas are becoming of significant concern for the mortality of long lived HIV immunocompromised patients AIDS-related lymphomas is an important field in cancer chemotherapy. Detailed understanding of the EBV lifecycle and related cancers at the molecular level is required for novel strategies of molecularlymphoma with EBV infection of the tumor clone has several pathogenetic, prognostic and possibly therapeutic implications which are reviewed herein.