Sensitization to Local Seafood Allergens in Adult Patients with Atopic Dermatitis in Malaysia (original) (raw)

International Archives of Allergy and Immunology

Abstract

Background: Seafood is an important source of nutrition in Asia. However, it was believed to cause or aggravate atopic dermatitis (AD). Objectives: We aim to determine relevant seafood sensitization among adults with AD and investigate cross-sensitization to aeroallergens. Methods: One hundred thirty-two adults with AD who were subjected to skin prick test (SPT) with 7 common local seafood allergens (anchovy, tuna, mackerel, squid, giant freshwater prawn, shrimp, and crab), house dust mites (HDMs), and cockroach were analyzed retrospectively. Results: The median age of the study subjects was 32 years (range 17–77 years) with a male to female ratio of 1:3. The mean duration of AD was 16 years. Eighty-two patients (62.2%) had other atopic conditions. Using SCORAD, 44.7% had mild, 42.4% moderate, and 12.9% severe disease. Eighty-six patients (65.2%) self-reported to have seafood allergy, with the main symptoms of transient pruritus and erythema within 2 h of ingestion. SPT revealed 51....

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