Evaluation of povidone Iodine 10% versus 7.5% hand scrub in cesarean section wound infections: A prospective trial (original) (raw)
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Trials, 2021
Objectives: To compare the efficacy of chlorhexidine-alcohol and povidone-iodine as preoperative antiseptic skin preparation for prevention of surgical site infection (SSI) after cesarean delivery (CD). Materials and methods: A total of 311 eligible women who underwent CS were recruited in the study after fulfilling all the eligibility and exclusion criteria. Patients were randomized into two groups (153 in chlorhexidinealcohol group and 158 in povidone-iodine group) by a computer-generated randomization table. Patients were followed for a period of 30 days in postoperative period to monitor for SSI. Results: The rate of SSI in the chlorhexidine-alcohol group is 5.4% and that of the povidone-iodine group is 8.6%. E. coli, K. pneumoniae, and Acinetobacter baumannii were the most common organisms isolated. E. coli was found in 9.5% of the total SSI cases. Conclusions: The study found that the patients who received chlorhexidine-alcohol as skin antiseptic had less chance of developing SSI than those who received povidone-iodine; however, it did not reach a statistical significance.
International journal of scientific research, 2020
Objective: To evaluate the efficacy of pre-cesarean vaginal wash using 5% Povidone Iodine solution on rate of post-cesarean section (CS) surgical site infection and compared with No swabbing. Method: A Prospective Randomized controlled Trial was conducted in department of Obstetrics and Gynecology in Government medical college, Aurangabad. In interventional group, vaginal swabbing with a gauze pieces impregnated with 5% Povidone Iodine solution was done for 30 seconds. The swabbing of vagina was not performed in cases assigned to control group, however the standard surgical preparation of abdomen was done in a usual manner for both group. All subject received prophylactic antibiotic cover. Collected data was complied in pre-designed proforma and analysis was done using SPSS 15. Result: The risk of post operative fever and wound infection was significantly reduced in interventional group. No measure difference was noted in seroma and composite wound infection. Also less duration of h...
Antiseptic Skin Preparation for Preventing Surgical Site Infection at Caesarean Section
Open Journal of Obstetrics and Gynecology, 2016
Purpose: To compare the effect of chlorhexidine-alcohol and povidone iodine on surgical site infection (SSI) after caesarean section. Methodology: A randomized control trial of 374 patients (188 in the chlorhexidine-alcohol group and 186 in the povidone iodine group) who had elective caesarean section with no overt risk for SSI was done. Patients were followed up until thirty days after delivery to assess for symptoms and signs of SSI. Results: Fifty-one (13.6%) of the study population developed SSI. Although the incidence of SSI was lower in the chlorhexidine-alcohol group than the povidone iodine group (12.2% vs. 15.1%; p = 0.26); the difference was not statistically significant. The incidence of adverse skin reaction in Chlorhexidine-alcohol vs. povidone iodine was also not statistically significant (4.0% vs. 5.4%; p = 0.40). Conclusion: The study demonstrates that there was no statistically significant difference in antiseptic property and side effect profile of chlorhexidine-alcohol and povidone-iodine when used as skin antisepsis in caesarean section.
American Journal of Obstetrics & Gynecology MFM, 2019
BACKGROUND: Several randomized controlled trials have demonstrated that preoperative abdominal skin preparation with chlorhexidine gluconate is superior to povidone-iodine for the prevention of surgical site infections. Despite these results, povidone-iodine is still the most commonly used agent for vaginal preparation, even though it may not be ideal. OBJECTIVES: The objectives of the study were as follows: (1) to determine whether vaginal cleansing with a 4% chlorhexidine gluconate solution results in fewer wound infections as compared with povidoneiodine when used for vaginal antisepsis prior to cesarean delivery and (2) to compare rates of patient reported side-effects associated with vaginal application of 4% chlorhexidine gluconate solution and 10% povidone-iodine. STUDY DESIGN: This is a block randomized, comparator-controlled, open-label trial. Women undergoing nonemergent cesarean delivery were randomized to receive vaginal cleansing with either 4% chlorhexidine solution or 10% povidone-iodine solution prior to skin incision. The primary outcome was wound site infection occurring within 14 days of cesarean delivery including superficial or deep surgical site infection. Secondary outcomes included rates of endometritis, postoperative fever, and side effects (vaginal dryness, irritation, and desquamitization) occurring within 14 days of cesarean delivery. Risks were reported as odds ratios with 95% confidence intervals, with P < .05 considered as significant.
The Egyptian Journal of Hospital Medicine, 2021
Background: Cesarean section is the most performed major abdominal surgery. While cesarean delivery is usually an uncomplicated procedure, up to 20% of patients can experience a complication following cesarean delivery with infectious complications being the most common. Nosocomial infections represent one of the major sources of morbidity and mortality in hospitalized patients around the world. Objective: The aim of the current work was to evaluate if the different scrubbing methods of surgical team before cesarean section by different materials change the rates of post-operative surgical site infection or not. Patient and methods: This randomized controlled trial (RCT) study included a total of 278 pregnant women, attending
IOSR Journals , 2019
Introduction: Healthcare-Associated Infections (HAIs) is a subject of great concern of the healthcare services. Surgical Site Infection (SSI), among the topographies of the HAIs, is directly related to surgical procedures, and is currently one of the most important among the HAIs. Surgical site infection is serious complication of surgery with significant impact on morbidity and mortality. However, Povidone-iodine has been utilized as a broad-spectrum antiseptic irrigation solution in the wound management processes for many years but some recent studies showed that the infection rate in laparotomy wounds decreases more by using normal saline. Objectives: In the background of postoperative infection and associated morbidity-mortality, this prospective study compares the efficacy of Povidone-iodine and Normal Saline in Preventing Surgical Site Infections in laparotomy and laparoscopic wounds. Method: The patients undergoing elective laparotomies and laparoscopic procedures were included and randomly assigned to 2 groups. In the first group (118 patients), incision wounds were flushed with 5% povidone-iodine solution. In the second group (118 patients), incisions were flushed with 0.9% normal saline solution. By comparing the infection rates of the wound outcomes were measured between the two groups. Result: Surgical site infections were seen in 25 of 236 (10.5%) patients 14 in povidone-iodine versus 11 in normal saline groups. The difference in the infection rates in the two studied groups has no statistical significance. Conclusion: There is not increase or decrease in the in the rate of SSI in laparotomy and laparoscopic wounds irrigation with 5% Povidone-iodine compared to irrigation with 0.9% saline solution.
Impact of preoperative vaginal preparation with povidone iodine on post cesarean infection
Caspian Journal of Reproductive Medicine, 2016
Background: Obtaining clinical methods in order to decrease the infectious morbidity of cesarean delivery is very important. The aim of this study was to determine the effect of preoperative vaginal preparation with antiseptic solution on post-caesarean infections. Methods: This study was conducted on 400 singleton term pregnant women undergoing elective cesarean delivery. The samples were randomized into two groups; experimental group, including women who received an additional preoperative vaginal cleansing with 10% povidone iodine; and a control group, including women who received only the standard abdominal preparation. All subjects received a single dose of prophylactic antibiotic and were investigated after cesarean delivery until the 6th postoperative weeks for postoperative fever, wound infection, or endometritis. Data were analyzed using SPSS software and the P value < 0.05 was considered significant. Results: The groups were similar in age, education level, body mass index, and parity. The operation variables such as the postoperative fever, wound infection, and endometritis were observed in the two groups, and the overall for these were found to be 6.0 %, 6.3%, and 6.5%, respectively. A total of 7.5% of the participants in the control group and 5.5% of the participants in the experimental group developed postoperative endometritis; but it was not statistically significant (relative risk= 0.86; 95% confidence interval, 0.61-1.21; P=0.417). Also, there was no significant difference in postoperative fever, wound infection between these women with and without preoperative vaginal cleansing with povidone. Conclusion: The findings of the present study indicated that vaginal cleansing with povidone iodine immediately prior to elective cesarean delivery did not decrease the post-caesarean infection rates and the incidence of endometritis in low-risk women.
Journal of Critical Care Nursing, 2016
Background: Hand disinfection is a major part of infection control during a surgical procedure. In contrast to developed countries, where the use of alcohol-based solutions (ABS) is routine, the usual practice in Iran is hand scrubbing using Povidone Iodine Solution (PVI). Most researchers have concluded that ABS might be superior to PVI, but others have found no differences. In this study the disinfection efficacy of ABS was compared to PVI. Methods: Thirty-one volunteers including surgeons and operating room nurses (OR-nurses) participated in this cross over design study. For one week they used ABS and the next week they used PVI for pre-surgical hand disinfection. Samples were obtained from the hands of all participants before, immediately after and two hours after hand washing. The bacterial contamination rate was evaluated by a microbiologist. Results: Our results demonstrated that ABS led to significantly lower mean Colony Forming Units (CFU) immediately after hand disinfection, but no significant differences were found between the two groups after two hours. Also, alcohol-based solution revealed a significantly higher logarithmic reduction factor (RF) of skin flora as an instantaneous effect. Both solutions were effective against Staphylococcus aureus, but the minimum reduction rate was in eliminating the Bacillus group. Conclusions: In conclusion, ABS can be promoted as the best choice for surgical hand disinfection solution amongst emergency situations, in that it has a time saving character and better instantaneous effect on bacterial skin flora reduction.
The aim of the present study is to evaluate the efficacy of povidone iodine alone and in combination with antiseptic agent containing alcoholic chlorhexidine in preoperative skin preparation by taking swab culture and to compare the rate of postoperative wound infection in both the groups. Patients and methods: This hospital based comparative study includesSixty Patients (Thirty in each Group) with no focus of infection on the body undergoing clean elective surgery at Siddhartha Medical College and General Hospital from 1 st July 2017 to28 th February 2018. Results: When compared to povidone iodine alone, using a combination of povidone iodine and alcoholic solution of chlorhexidine, wound infections were lesser and the colonization rates of the site of incision were reduced significantly. Hence Preoperative skin preparation with chlorhexidine gluconate 2.5% v/v in 70% propanol followed by aqueous povidone-iodine is an ideal regime as it has a broader antimicrobial spectrum and the rate of postoperative wound infections is much lower as compared to povidone iodine alone.
JPMA. The Journal of the Pakistan Medical Association, 2015
To compare the efficacy of povidone-iodine and chlorhexidine gluconate scrubs in preventing surgical site infections. The randomised controlled clinical trial was conducted from May 2012 to April 2013 in two public-sector hospitals of Pakistan; one each in Karachi and Islamabad. Patients undergoing clean or clean contaminated surgeries were included and were randomly assigned to one of the two groups: group I comprised patients whose skin was preoperatively disinfected using 10% povidone-iodine, and in group II by 2% chlorhexidine gluconate in 70% alcohol. A predesigned proforma was filled for all patients to record demographic data, diagnosis, surgical procedure and antibiotic used. Patients in both groups were followed up for one month postoperatively to monitor any signs of surgical site infections. SPSS 16 was used for statistical analysis. Of the 388 patients from the two hospitals, 220(57%) were in group I and 168(43%) were in group II. Surgical site infection was observed in ...