Dosimetric validation of two different radiobiological models for parotid gland functionality of tongue cancer (original) (raw)

Objective: The aim of this study was to investigate the normal tissue complication probability (NTCP) for parotid gland of ca tongue patients from two different radiobiological models and to establish a dosimetric validity. Methods: Lyman-Kutcher-Burman (LKB) model and linear quadratic (LQ) model were considered for determination of NTCP and tolerance dose (TD 5/5 and TD 50/5) for the parotid gland of 67 number of ca tongue patients who were treated with the volumetric arc therapy (VMAT) technique. An in-house developed software on Excel (VBA) was used for this study. Results: The equivalent uniform dose (EUD) was linearly proportional to the effective volume (v eff) for parotid glands and there was a strong correlation between EUD and v eff. At EUD = 46 to 47 Gy, the NTCP of parotid was 0.5 for both the models. The tolerance doses, TD 5/5 (v eff) and TD 50/5 (v eff) were exponentially reduced with increase of v eff for LKB model; whereas these parameters were volume-independent in the LQ model. TD 5/5 (v eff) and TD 50/5 (v eff) were 31.98 Gy and 45.98 Gy respectively for all 67 patients in the LQ model. Below TD 50/5 , NTCP of LKB model was less than the NTCP , calculated from LQ model. Conclusion: One may consider radiobiological LQ model for estimation of clinical tolerance dose for OARs. Due to lack of clinical data, there are inaccuracy in determination of NTCP from LQ model. If sufficient number of tolerance data for partial volumes are available, the prediction of NTCP would be more confident. K E Y W O R D S effective volume, equivalent uniform dose, Lyman-Kutcher-Burman model, normal tissue complication probability, radiobiological model This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.