Safety, Tolerability, and Efficacy of Azilsartan Medoxomil With or Without Chlorthalidone During and After 8 Months of Treatment for Hypertension (original) (raw)
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2022
Aims: This study intends to compare AZI-M/CT’s efficacy and side effect profile to the OLM/HCTZ in hypertensive patients. Materials and methods: Online databases (PubMed, Google Scholar, and ClinicalTrials.gov) were searched until January 15, 2022, for original articles exploring the effects of AZI-M/CT on pertinent outcomes among hypertensive patients in contrast to OLM/HCTZ. Data on baseline characteristics and endpoints were extracted. Review Manager version 5.4.1 and STATA 16.0 were used for analyses. Risk ratios (RR) and the weighted mean differences (WMD) with corresponding 95% confidence intervals were calculated. Results: Four studies were included having 3146 patients in total (AZI-M/CT: 1931 and OLM/HCTZ: 1215). The pooled analysis exhibited that compared to OLM-HCTZ, mean DBP was significantly lower in the AZI-M/CT group (WMD –2.64 [-2.78, -2.51]; p= <0.00001, I2= 1%), whereas no significant differences were noted in mean SBP (WMD –2.95 [-6.64,0.73]; p= 0.12, I2=100%)...
Journal of hypertension, 2018
Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, has been developed in fixed-dose combinations (FDCs) with chlorthalidone (CTD). We compared FDCs of AZL-M/CTD 20/12.5 mg once daily titrated to 40/25 mg if needed or AZL-M/CTD 40/12.5 mg once daily titrated to 80/25 mg if needed with an olmesartan medoxomil (OLM)-hydrochlorothiazide (HCTZ) 20/12.5 mg FDC once daily titrated to 40/25 mg if needed in a randomized, double-blind, 8-week study of 1085 participants with clinic SBP 160-190 mmHg and DBP 119 mmHg or less. Titration to higher doses occurred at week 4 if BP was at least 140/90 mmHg (≥130/80 mmHg if diabetes or chronic kidney disease). The primary endpoint was change from baseline in clinic SBP; 24-h ambulatory BP monitoring was also measured. Greater reductions in clinic SBP from a baseline of 165 mmHg were observed (P < 0.001) in both AZL-M/CTD arms (-37.6 and -38.2 mmHg) versus OLM/HCTZ (-31.5 mmHg), despite greater dose titration in the OLM/HCTZ group. At ...
International Journal of Hypertension
This phase 4 study evaluated the efficacy and safety of azilsartan medoxomil (AZL-M) in patients with essential hypertension and type 2 diabetes mellitus (T2DM) in Hong Kong, Taiwan, and Thailand. This was a prospective, multicenter, single-arm, open-label study with patients aged 18–75 years with T2DM and essential hypertension and on stable treatment for T2DM. Patients with uncontrolled hypertension were treated with AZL-M 40 mg daily, with the option to uptitrate to 80 mg at 6 weeks. In all, 380 of the 478 patients screened in Hong Kong, Taiwan, and Thailand were enrolled. At week 6, 97 patients (25.5%) were titrated up to AZL-M 80 mg based on BP readings. At 12 weeks, 54.8% of patients reached the blood pressure (BP) goal of <140/85 mm Hg by trough sitting clinic BP (primary endpoint), and 62.8% and 27.0% achieved a BP of <140/90 mm Hg and <130/80 mm Hg, respectively. The efficacy of AZL-M over 12 weeks was also seen in different age and body mass index groups. The inci...
https://www.ijrrjournal.com/IJRR\_Vol.6\_Issue.10\_Oct2019/Abstract\_IJRR0054.html, 2019
Aims and Objectives of Study: Hypertension statistics had reported that approximately 9 million lives/per annum are at risk due to increased blood pressure. Azilsartan Medoxomil is an angiotensin inhibitor, widely used as a single treatment regime or in combination with other drugs is an FDA approved therapeutic that has a significant impact in hypertension patients. The present study is a prospective observational study with (a) Primary objective: to evaluate efficiency of Azilsartan (40mg / 80mg) as single treatment regime or with added drug, (b) Secondary objective: to assess the control statistics of hypertension in patients with/ without comorbidity. Methodology: A total of 120 patients were screened and 100 subjects fulfilled the inclusion criteria with a hypertensive cut off value of 130/80 mmHg. Patients were subjected to Azilsartan monotherapy dosage (40mg/80mg) and combinatorial Azilsartan treatment with added drug. The following data was collected and analyzed for all study subjects enrolled in this observational study: Demographic details, Comorbidity associated with hypertension, Measurements of Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Measurements of Systolic blood pressure (SBP3m) and Diastolic blood pressure (DBP3m) after 3 months of drug treatment. Results: The study population was predominantly of 51-60 years age group. Prevalence of hypertension at a gender level clearly showed that male population with 63% enrollment in study are at an increased risk in comparison to 37% patient enrollment noted in female population. Medical comorbidity ailments including Coronary Artery Disease, Diabetes Mellitus, Rheumatic Heart Disease. Azilsartan dosage (40mg/80mg) with either single treatment regime or combinatorial treatment regime with added drugs caused effective reduction in blood pressure during the study period. Conclusion: Combinatorial treatment regimens of Azilsartan (40mg/80mg) along with added drug, proved more effective in significantly lowering blood pressure levels.