Soft drink consumption reduces food intake in Wistar rats (original) (raw)
Related papers
2021
Ultra-processed food consumption, which is highly palatable, rich in fat, sugar, and salt causes uncontrolled food intake and has contributed to a sharp increase in obesity worldwide. This study evaluated the effects of soft drink and/or ultra-processed food intake on eating behavior and metabolic parameters in rats fed with a cafeteria diet. Male Wistar rats were divided into six groups. 1) CON: standard chow and water; 2) CD: cafeteria diet, standard chow, and water; 3) CS: caloric soft drink, standard chow, and water; 4) NCS: non-caloric soft drink, standard chow, and water; 5) CD + CS: cafeteria diet, caloric soft drink, standard chow, and water; and 6) CD + NCS: cafeteria diet, non-caloric soft drink, standard chow, and water. The cafeteria diet intake resulted in higher energy consumption (30% increase on average), a 450% increase in lipid consumption, and a 50% reduction in protein intake, which contributed to a 60% increase in body weight relative to the controls. This diet ...
The metabolic disorders associated with chronic consumption of soft and energy drinks in rats*
Acta Biochimica Polonica
Background: Energy Drinks (EDs) and Soft Drinks (SDs) are widely consumed among adolescents and young adults. These drinks contain variable amounts of caffeine which is a central nervous system stimulator; in addition to sugar, taurine, vitamins and herbal extracts. Several adverse effects have been reported for the excessive consumption of caffeine and sugar. Aim: This work aimed at providing a comparison between the effect of chronic consumption of both drinks on metabolism biochemically as well as at the histopathological level. Methods: Adult albino rats were randomly divided into three groups and treated for 4 weeks. Animals received water (control, group 1), 12.5 ml/kg/day of either Pepsi® (SD, group 2) or Power Horse® (ED, group 3). All animals had free access to water and standard animal chow. Results: ED and SD groups showed a significant weight gain compared to control. ED animals showed a significant increase in serum urea, hyperlipidemia and hyperglycemia in comparison t...
The study was carried out to discover the effects of the oral intake of some soft drinks (Fanta, Sprite, Fayrouz, Coca-cola and Schweppes) on blood glucose level and lipid profile of albino rats. The rats were grouped into 6 each containing 4 rats, and were allowed to fast for 12hrs, their fasting blood glucose was taken to know their pre treatment fasting blood glucose level. Group 1 was administered with normal saline, group 2 was given Fanta, group 3 was given Sprite, group 4 was given Schweppes, group 5 was given Fayrouz and group 6 was given Cocacola. All the groups were administered with 3ml of the soft drink per 100g body weight twice a day respectively throughout the period of the research. The research lasted for 14 days. On the last day the rats were allowed to fast again for a period of 12hrs after which the fasting blood glucose level was determined; finally, the rats were sacrificed by cervical decapitation and the serum collected for the determination of lipid profile. There was statistical difference (p<0.05) in fasting blood glucose between the pre-treatment and post-treatment values. Group 2 (Fanta fed rats) and Group 6(Coca-cola fed rats) showed high level of glucose (p<0.05) compared to normal control, while the groups administered with Sprite, Schweppes and Fayrouz respectively showed no statistical difference in fasting blood glucose level when compared to the normal control. In the analysis of lipid profile, the group administered with Fanta exhibited high level of total cholesterol, low level of triglyceride and low density lipoprotein and normal level of high density lipoprotein. The group given Coca-cola showed low level of total cholesterol, triglyceride, high density lipoprotein and normal level of low density lipoprotein, while the group given Schweppes showed high level of total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein. The group given Fayrouz showed high level of Cholesterol, low density lipoprotein and low level of Triglyceride and high density lipoprotein. Lastly, the group given Sprite showed no statistical differen ce in all these parameters when compared to the control group. Therefore, it was concluded that among the various soft drinks used in the present study, it was only Sprite soft drink that appeared not to be implicated as a predisposing factor to any of the diseases considered. Keywords: Soft drinks, Predisposing factor, Diabetes melitus, cardiovascular diseases, Lipid profile, Fasting blood glucose.
The Effects of Soft Drinks on Some Physiological and Biochemical Parameters in Male Albino Rats
JOURNAL OF EDUCATION AND SCIENCE, 2019
The present study aimed to investigate the effects of soft drinks such as Cola and Miranda on some physiological and biochemical parameters in the blood of white rats such as body weight (B.W), hemoglobin (HB), blood glucose (B.G) concentration and estimation of lipid profile estimation which included: total cholestrol (TC), triglycerides (TG), low density lipoprotein (LDL-c), high density lipoprotein (HDLc), total protein as well as estimating the concentration of urea and creatinine in the blood serum of male albino rats treated for one month. The results showed significant differences (p≤0.05) in some parameters compared with control group like body weight, blood glucose concentration and lipid profile, while other values such as concentration of hemoglobin, urea and total protein showed no significant differences with control group. These results show the relationship of soft drinks and their harmful effects on public health as well as their cause of metabolic syndromes such as obesity, heart disease, diabetes and high blood lipids.
Hyperglycemic and Hyperlipidemic Effect of Some Coca-Cola Soft Drinks in Wistar Rats
Acta Scientific Nutritional Health
Carbonated soft drinks are sweetened water-based nonalcoholic beverages mostly with balance acidity [1]. They are also known as ready-to-drink beverages. Soft drinks are frequently flavored and coloured and the principal component being water which is needed for hydration. Soft drinks are commonly consumed by both young and old people [2,3]. A notable finding of Wolff and Dangsinger [4] was that weight gained was more dramatic from soft drinks compared with fruit punches and fruit juice. In addition, intake of fruit juice was not associated with an increased risk of type-2 diabetes. This could be because of the low glycemic index (GI) of fruit juice, soluble fibre, or other constituents of fruit juice that could be beneficial, as the authors suggested [5]. Previous study revealed that a woman with high intake of sugar-sweetened soft drinks tends to be less physically active; in addition, she has high total calories and low protein, alcohol, magnesium and cereal fiber [4]. Also, intake of total carbohydrate, sucrose and fructose as well as overall glycemic index was high in this woman. In essence this woman has dietary pattern and lifestyle that lead to increased risk of several disease states, including obesity, type-2 diabetes and cardiovascular diseases [6].
Consumo de refrigerante reduz a ingestão de alimentos em ratos Wistar
Scientia Medica, 2016
Aims: To evaluate the effect of caloric and non-caloric soft drink intake on food consumption, body weight and composition, and metabolic parameters in rats. Methods: Controlled experimental study in which 30 male Wistar rats were divided into three groups and given food and beverage ad libitum during 17 weeks. The groups were as follows, according to the offered food: Control group-standard chow and water; Caloric soft drink group-standard chow, caloric soft drink, and water; and Non-caloric soft drink group-standard chow, non-caloric soft drink, and water. Results: There was no statistical difference in total energy intake, body weight, and fat deposition between groups. However, the chow energy intake was 45% lower in the caloric soft drink group compared to the control and non-caloric soft drink groups (198.7±0.7 kJ vs. 349.4±2.0 and 373.0±1.3 kJ, respectively), with 46% of the energy provided by the soft drink. The caloric soft drink group consumed 22% more carbohydrate, especially sucrose, compared to the control group (p<0.05). Macronutrient intake was not different between the control and non-caloric soft drink groups, but the caloric soft drink group consumed less protein and lipids when compared to the other groups (3.5±1.0 g of protein vs. 6.2±0.1 and 6.7±0.1 g, respectively; 0.7±0.01 g of lipids vs. 1.3±0.02 g and 1.4±0.02 g, respectively). Consumption of non-caloric soft drinks increased total sodium intake and consumption of both soft drinks decreased water intake. Although body weight varied during the experiment, there was no significant difference between groups at the end of the experiment, and no difference in fat deposition, fasting glucose, insulin and leptin, insulin resistance index, and lipid profile. Conclusions: The consumption of both types of soft drinks did not affect energy intake, body weight and composition, or metabolic parameters; however, it increased fluid intake and decreased water ingestion. Caloric soft drink intake influenced the amount and the quality of solid food consumed, compromising diet quality.
Nutrients
We investigated whether the long-term intake of a typical sugar-sweetened soft drink (sugar-sweetened beverage, SSB) alters markers for taste function when combined with a standard diet (chow) or a model chow mimicking a Western diet (WD). Adult male CD1 mice had ad libitum access to tap water or SSB in combination with either the chow or the WD for 24 weeks. Energy intake from fluid and food was monitored three times a week. Cardiometabolic markers (body weight and composition, waist circumference, glucose and lipid profile, and blood pressure) were analyzed at the end of the intervention, as was the number and size of the fungiform papillae as well as mRNA levels of genes associated with the different cell types of taste buds and taste receptors in the circumvallate papillae using a cDNA microarray and qPCR. Although the overall energy intake was higher in the WD groups, there was no difference in body weight or other cardiometabolic markers between the SSB and water groups. The c...
Physiology & Behavior, 2016
For more than a decade, pioneering animal studies conducted by investigators at Purdue University have provided evidence to support a central thesis: that the uncoupling of sweet taste and caloric intake by low-calorie sweeteners (LCS) can disrupt an animal's ability to predict the metabolic consequences of sweet taste, and thereby impair the animal's ability to respond appropriately to sweet-tasting foods. These investigators' work has been replicated and extended internationally. There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs-including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol + aspartame-have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or-in many caseseven to calorically-sweetened foods or liquids. Adverse impacts of LCS have appeared diminished in animals on dietary restriction, but were pronounced among males, animals genetically predisposed to obesity, and animals with diet-induced obesity. Impacts have been especially striking in animals on high-energy diets: diets high in fats and sugars, and diets which resemble a highly-processed 'Western' diet, including trans-fatty acids and monosodium glutamate. These studies have offered both support for, and biologically plausible mechanisms to explain, the results from a series of large-scale, long-term prospective observational studies conducted in humans, in which longitudinal increases in weight, abdominal adiposity, and incidence of overweight and obesity have been observed among study participants who reported using diet sodas and other LCS-sweetened beverages daily or more often at baseline. Furthermore, frequent use of diet beverages has been associated prospectively with increased long-term risk and/or hazard of a number of cardiometabolic conditions usually considered to be among the sequelae of obesity: hypertension, metabolic syndrome, diabetes, depression, kidney dysfunction, heart attack, stroke, and even cardiovascular and total mortality. Reverse causality does not appear to explain fully the increased risk observed across all of these studies, the majority of which have included key potential confounders as covariates. These have included body mass index or waist circumference at baseline; total caloric intake and specific macronutrient intake; physical activity; smoking; demographic and other relevant risk factors; and/or family history of disease. Whether non-LCS ingredients in diet beverages might have independently increased the weight gain and/or cardiometabolic risk observed among frequent consumers of LCS-sweetened beverages deserves
Effects of Soft Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis
American Journal of Public Health, 2007
In a meta-analysis of 88 studies, we examined the association between soft drink consumption and nutrition and health outcomes. We found clear associations of soft drink intake with increased energy intake and body weight. Soft drink intake also was associated with lower intakes of milk, calcium, and other nutrients and with an increased risk of several medical problems (e.g., diabetes).
Chronic consumption of fructose rich soft drinks alters tissue lipids of rats
Diabetology & metabolic syndrome, 2010
Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink. Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks. The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls. Based on the results, it can be concluded that daily i...