Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax (original) (raw)

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Cholera toxin (CT) is recognized for its potent mucosal-vaccine adjuvant properties, primarily mediated through the induction of Th17 cells. This study demonstrates that CT effectively induces IL-17-producing CD4 Th17 cells, which play a crucial role in generating both serum and mucosal antibody responses against inhalation anthrax. The induction mechanism involves cAMP-dependent secretion of specific cytokines by dendritic cells, suggesting a targeted approach for developing non-toxic mucosal adjuvants.

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