A Rare Presentation of Cutaneous Metastases in Advanced Lung Adenocarcinoma (original) (raw)

Synchronous thyroid and colon metastases from epidermoid carcinoma of the lung: case report

Sao Paulo Medical Journal, 2010

CONTEXT: Non-small cell lung cancer (NSCLC) progresses to distant metastases in most cases. The most frequent sites for distant metastases are the bones, central nervous system, adrenal glands and liver. Dissemination to the skin, myocardium, thyroid gland and intestine may occur, but is rare. CASE REPORT: We describe a case of squamous cell carcinoma in the lungs, with metastases in the colon and thyroid, in a 66-year-old female patient. The lesion was unresectable and chemotherapy was started. The patient evolved with intestinal subocclusion, and colonoscopy showed the presence of a polyp. Biopsy and immunohistochemical analysis on the polyp showed that it was compatible with squamous cell carcinoma of pulmonary origin. At a follow-up consultation, the patient presented a thyroid nodule. A aspiration biopsy and cellblock immunohistochemistry confirmed the squamous cell carcinoma of pulmonary origin. After third-line chemotherapy, the patient progressed with acute obstructive abdom...

Lung adenocarcinoma with thyroid metastasis: a case report

BMC research notes, 2017

The metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases. Three years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. Clinical examination revealed a right thyroid nodule. Chest and neck computed tomography (CT) scan showed a proximal left tumor in contact with the pulmonary artery and revealed a suspected nodule in the right lobe of the thyroid with homolateral neck node. Transbronchial biopsy was performed and pathological examination revealed adenocarcinoma of the lung and positive for thyroid transcription factor. Other explorations carried out, such as brain CT, bone scan and abdominal ultrasound were normal. After a repeated negative fine needle aspiration biopsy of the suspected nodule of the right lobe of the thyroid, we performed total thyro...

Cutaneous metastasis from carcinoma of lung

Indian dermatology online journal, 2013

A 65-year-old male with a history of smoking since 30 years presented with breathlessness, hemoptysis, multiple swellings all over the body, and weakness in September 2010 at our hospital. Clinically, a diagnosis of chronic obstructive pulmonary disease (COPD) with cutaneous lymphoma or soft tissue tumor was made. Chest X-ray (CXR) and computed tomography (CT) scan revealed a neoplastic lesion in the right lung with secondary cavitation. Biopsy of the cutaneous nodules showed metastatic deposits from squamous cell carcinoma. Metastatic skin cancer is a relatively rare complication of internal malignancy. The clinical features of metastatic skin disease vary enormously. They may present as erysipeloid, sclerodermoid, alopecia neoplastica or in an inflammatory or bullous form or as multiple nodules as in our case. A high index of suspicion for metastatic deposits is required in an elderly male patient who is a known case of lung cancer or even one who is a chronic smoker and presents ...

Cutaneous metastasis of carcinoma lung: a rare cytological association

Skin metastasis is an uncommon presentation of cancer. Cutaneous metastases as initial manifestation of internal neoplasms, represent only 0.8% of total cases and implies, in general, a very advanced grade of the disease and short survival. Metastasis to the skin from lung cancer is less common than metastasis to other organs. The incidence of skin metastasis was 2.8% among all 579 cases of lung cancer. Large cell carcinoma showed the greatest tendency to spread to the skin and epidermoid carcinoma showed the least tendency. Back of the trunk was the most common site for metastatic cutaneous lesions. Almost all lesions ranged from 1 to 5 cm in diameter. Clinical manifestation of skin metastasis was nodular type in all the cases and was accompanied by metastasis to other organs at the time of clinical presentation. A slight response to combination chemotherapy was noted in only 5 cases of lung cancers, with most lesions being progressive. Median survival after skin involvement was ap...

Cutaneous Metastasis in a Case of Adenocarcinoma of the Lung: A Cytological Diagnosis

Middle East Journal of Cancer, 2015

Subcutaneous metastatic nodules are an uncommon first sign of underlying cancer. Cutaneous metastasis occurs in 0.8% to 4% of all cancer patients and less than 5% in those with lung cancer. These metastases are usually single or multiple painless nodules that may be mobile or fixed. Cutaneous metastases from the lung are not very common and indicate a worse prognosis. The limited literature on skin metastases from a primary lung suggests that if other extracutaneous metastases exist, median survival does not exceed three months; however, if the skin is the only site of metastatic disease, survival can reach ten months. Fine needle aspiration cytology is an excellent noninvasive method for early diagnosis of subcutaneous nodules, which in the presence of characteristic cytomorphology obviates the need for more invasive methods and surgery. Once diagnosed, the aim is to start treatment as soon as possible before widespread visceral metastases occur. Although the response to chemothera...

Isolated thyroid metastasis revealed an unknown lung adenocarcinoma: a case report

Journal of Medical Case Reports, 2015

Introduction: Cancer metastasis to the thyroid is extremely rare. The most common sites that have been reported to metastasize to the thyroid gland are breast and kidney. As to primary lung cancer metastasizing to the thyroid gland, only a few cases have been described in the literature. Case presentation: We report a case of a 37-year-old white Arabian woman who had never smoked tobacco products for whom a malignant thyroid mass revealed a primary lung tumor. She had a surgical excision for both the thyroid and the pulmonary tumors, and received adjuvant chemotherapy. At 1 year, she is still in remission. Conclusions: Our case is rare as it describes a case where the thyroid lesion was the revealing sign of an unknown lung carcinoma. Management of thyroid metastases should depend on the individual situation and surgical excision should be proposed whenever a patient's condition is favorable.

Skin metastases from lung cancer: a case report

BMC Research Notes, 2015

Background: Lung cancer is one of the most frequent malignancies, with high mortality rates. It can metastasize in almost all organs, but more often invades hilar nodes, liver, adrenal glands, bones and brain. There are various data on the incidence of lung cancer metastases in the skin. In 1-12% of patients with lung cancer are developed skin metastases. Metastases in the skin may be the first sign of lung cancer. Case presentation: Forty-five years old Albanian male, smoker, was admitted to our department with multiple nodules localized in the skin of the head, neck, back and chest. The nodules measuring 5-15 millimeters in greatest dimension were round and skin-colored, with telangiectasias, firm and tender. They appeared in an eruptive form about two weeks before being admitted at our hospital. In addition, the patient exhibited signs of weight loss, anorexia and fatigue. Excisional biopsy was performed to one of the lesions. Histopathology confirmed metastatic nature of the lesion namely, malignant tumor of neuroendocrine phenotype consistent with small-cell carcinoma. Chest X-ray and computed tomography revealed an expansive process in the 7 th segment of the left lung, left hilar and mediastinal lymphadenopathy and a suspicious initial secondary deposit in the left adrenal gland. The patient was referred to the department of oncology for further treatment. After the third cycle of chemotherapy, the magnetic resonance imaging revealed brain metastases. The patient passed away four months after the diagnosis of lung cancer first presented with skin metastases. Conclusions: Metastases in skin may be the first sign of lung cancer. Although rare appearing, we should raise suspicion in cases of atypical lesions in the skin not only of the smokers, but also of the non-smokers. Skin metastases from small-cell lung carcinoma are a poor prognostic indicator. The appearance of multiple skin metastases with other internal metastases shorten the survival time.

Cutaneous metastases as initial presentation of malignancy

BJR|case reports

We describe a case of 73-year-old female who presented with dry cough, chest pain and light-headedness. On examination, multiple subcutaneous masses were noticed on the chest wall, bilateral breast, anterior abdomen and both arms. Subsequent CT-TAP and CT-brain showed multiple subcutaneous nodules in scalp, neck, anterior chest wall, breast and abdomen. A biopsy taken from breast revealed metastatic malignant melanoma; however there was no evidence of primary cutaneous malignant melanoma. We also describe a case of 72-year-old male who presented with tender mass on his lower back and posterior neck. He was known to have COPD and was a heavy smoker. A CT-TAP showed right lower lung mass with soft tissue masses near lumbar spine and lower cervical spine. While awaiting bronchoscopy, biopsy taken from the mass on lower back showed features of metastatic lung adenocarcinoma. In fact, presence of cutaneous metastasis is herald sign and indicates advanced malignancy with poor prognosis regardless of type of primary malignancy.

Lung Carcinoma with Metastasis to Thyroid and Radius of Left Forearm, A Rare Case

Bioscience Biotechnology Research Communications, 2021

Adenocarcinoma of lung is commonest cancer of lung. Sufferings of this dreaded disease are mainly due to bony metastasis in the form of pain and pathological fractures. Unfortunately all the treatment option available for this malignancy are not proved useful. Present patient was a case of Adenocarcinoma of lung with complaint of cough since 10 months and swelling over left forearm since 2 months. On investigation found to have lung carcinoma with metastasis to right lobe of thyroid, radius of left forearm and skull and also having malignant pleural effusion. He was treated with palliative treatment including radiation and chemotherapy. After extensive search in literature it was found that only three cases were of thyroid metastasis from lung adenocarcinoma reported. All had metastatic disease .as disease was systemic and widespread hence obviously with bad prognosis. Our aim behind reporting this case is that as it is fourth case of thyroid metastasis from lung adenocarcinoma hence it is worth reportable and it suggest need of more extensive research to invent new effective anti-cancer drugs to decrease sufferings of these unfortunate patients. As this is advanced case of lung cancer there is no role of surgery. Palliative treatment including chemotherapy and radiotherapy seems to be not effective, hence it suggest need of more extensive research to invent new effective anti cancer drugs to decrease sufferings of these unfortunate patients.