RNA Structure Prediction (original) (raw)

Bioinformatics in Rice Research

One of the significant forms of molecules present in living cells is ribonucleic acid (RNA). RNA structural elements moderate various biological process, including epigenetic function, modify mRNA stability, and alternate splicing. The study of the secondary structures of RNA is, therefore, crucial for interpreting the role as well as the regulatory mechanism of RNA transcripts. But experimental methods are tedious, time-consuming, pricey, requires special equipment, and, thus, cannot often be implemented. Methods for statistical simulation are an option and parallel to experimental approaches. Additionally, the findings from the RNA-Puzzles, joint research on the estimation of RNA structures, suggest that computational methods can be employed for effective RNA modeling. However, there is still space for improvement. Considering this, in the chapter, authors attempted to understand the various forms of RNA and how computational approaches can be employed to predict their structure more precisely. The RNA