Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor (original) (raw)

2003, Cell Death and Differentiation

AI-generated Abstract

Caspase inhibition can prevent the mitochondrial release of apoptosis-inducing factor (AIF), a protein implicated in caspase-independent apoptosis. This study demonstrates that while AIF accumulation in mitochondria is non-toxic, only its cytosolic form promotes apoptosis. Experiments involving various cell lines show that the presence of caspase inhibitors like z-VAD-fmk can block the release of AIF in response to proapoptotic stimuli, suggesting a protective role of AIF against oxidative stress.

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