Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions (original) (raw)

2002, Journal of Physiology-london

AI-generated Abstract

This study investigates the regulatory mechanisms of the glutamine transporter SN1, focusing on the influence of extracellular pH and intracellular sodium concentrations on its function. Using Xenopus laevis oocytes, the research reveals that SN1 operates primarily via an electroneutral mechanism characterized by the cotransport of sodium ions linked to glutamine uptake and proton exchange. The findings highlight how alterations in pH and sodium levels can influence glutamine transport, posing significant implications for understanding metabolic processes in astrocytes and hepatocytes.

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