GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test (original) (raw)

O'NEILL, M. F., A. Cl. FERNANDEZ AND J. M. PALACIOS. CR 127935 blocks the locomotor and antidepressantlike effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. PHARMACOL BIOCHEM BEHAV 53(3) 535-539,1996.-The 5-HT ,A,B agonist RU 24969 induces hyperactivity in rodents and also shows antidepmssantlike effects in some animal models of depression. We have examined the effects of selective antagonists at 5-HT,, and 5-HT,, receptors (WAY 100135 and GR 127935, respectively) on both the hyperlocomotor and anti-immobility effects of RU 24969.