The Incidence and Risk Factors of Retinopathy of Prematurity in Sick Newborn Care Unit in a Tertiary Care Hospital in Eastern India - A Cross-Sectional Observational Study (original) (raw)
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IOSR Journals , 2019
Background: Retinopathy of prematurity (ROP) is an important cause of childhood visual impairment since the 1940s. Although its incidence and severity have been decreasing in developed countries over the past two decades, both are increasing in developing nations. The aim of this study to analyze risk factors for Retinopathy of prematurity and its incidence, in newborns at risk in SNCU of a tertiary care center of central India. Materials and Methods: Infants with birth weight less than 1500gm and gestation age less than 34 weeks were screened after birth at 4 weeks for ROP or 31-33 weeks post conception age, whichever was later from February 2015 to June 2016. Infants with birth weight 1500gm to 2500 gm and gestation more than 34 weeks with additional risk factors were also screened. Results: The incidence of ROP in this study was 33.70%. Mean birth weight and mean gestational age were significantly low in infants with ROP (p value < 00001). Oxygen supplementation, ventilator support, septicaemia, respiratory distress syndrome, apnoea and asphyxia were found to be significant risk factor for ROP development (p value < 0.05). However single or multiple pregnancies, Blood transfusion and hyperbilirubinaemia were not significant risk factor for ROP development in this study(p value>0.05). Conclusion: ROP is a multifactorial disease. Timely screening of at-risk neonates and infants can prevent development of advanced ROP which can lead to childhood blindness.
Indian Journal of Neonatal Medicine and Research, 2016
Introduction: Retinopathy of Prematurity (ROP), a disease characterized formation of a vascular barrier at junction of vascularized and non-vascularised retina is increasingly being common in developing countries due to increasingly improving neonatal fascilities. Various factors have been implicated in its causeation. Aim: Present study aimed to find prevalence of ROP and associated risk factors in rural tertiary care hospital setting. Materials and Methods: During study period, ROP screening and treatment was done by a trained retina specialist for neonates at 4-6 weeks after birth or at 31 weeks post menstrual age, whichever is later, using dilated indirect ophthalmoscopy with a 28 Dioptres condensing lens in Neonatal ICU. Risk factors including gestational age, birth weight and neonatal risk factors were noted and ROP, if present was classified and noted. Eligible babies were offered treatment. Results: Prospective study to screen 50 premature babies was undertaken over the stud...
2015
Retinopathy of prematurity (ROP) is a retinal disease that principally affects preterm neonates. It is recognized as the leading cause of preventable blindness and visual impairment in paediatric population, the major brunt of the disease affecting relatively immature newborns. An increase in survival of very young preterm infants, due to the advances in neonatology, have subjected them to the risk of developing ROP. This study has been undertaken to determine the incidence of ROP, its association with various clinical and social risk factors and also to study the vasculogenesis and outcome of the ROP positive cases detected in the course of screening.
Asian Journal of Medical Research, 2019
Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in the world. In India also as more and more premature babies are being saved the incidence is on the rise. Aim of this study is to know the incidence, prevalence and risk factors of ROP in preterm babies with birth weight < 1750 gms and /or gestational age < 35 weeks in a teaching hospital. Subjects and Methods: This study was conducted at Amala Institute of Medical Sciences from August 2016 to July 2018. All preterm babies < 1750 gms and/ or gestational age < 35 weeks and babies > 35 weeks and > 1750 gms with significant risk factors were screened for ROP. Results: Out of 202 babies, 180 babies fulfilled the criteria and completed the study. 12 babies did not meet the follow up criteria and 10 babies died before screening in the hospital. Out of 180 babies, 12 babies were found to have ROP with a prevalence rate of 6.7%.Conclusion: ROP is an important cause of preventable blindness in these vulnerable babies. Timely diagnosis and intervention will help to prevent the same.
IP International Journal of Ocular Oncology and Oculoplasty
Retinopathy of prematurity is a multi factorial vaso-proliferative disease that is the most common cause of preventable childhood blindness worldwide.This study aims to determine the frequency, clinical course and risk factors of ROP in premature infants treated in the Neonatal Intensive Care Unit (NNICU) of our hospital. In this retrospective observational study the case records of 243 infants who visited our ROP clinic between January 2020 and august 2021 were reviewed. The mean GA was 33.4 weeks and the mean birth weight was 1.3 kg. A total of 55 (22.82%) patients developed ROP. low birth weight (p value = <0.001), low gestational age (p value = <0.001), multiple pregnancy (p value 0.002), blood transfusion (p value = 0.033), sepsis (p value = 0.009, odds ratio = 2.29 at CI 95%), oxygen supplementation (p value = <0.001 odds ratio= 10.56 at CI 95%) and duration of oxygen (p value = <0.001, odds ratio =1.93 at CI 95%) were significant risk factor for development of ROP...
International Journal of Contemporary Pediatrics, 2017
Background: ROP is a disorder of the developing retinal blood vessels in the premature infant retina. Objective of present study is to determine the number of babies affected with ROP among the premature and low birth weight babies admitted to neonatal intensive care unit or attending neonatal follow up clinic at RRMCH Hospital during a period of one year.Methods: This is a prospective observational study conducted in Rajarajeswari Medical College and Hospital Bangalore for 12 months. All eligible babies were screened at Neonatal Intensive Care Unit where temperature is well controlled and the place to handle any emergencies. The pupils were dilated using 2.5% phenylephrine and 0.5% tropicamide eye drops instilled three times into each eye at intervals of 15 minutes about one hour before the scheduled examination.Results: 100 babies were screened and followed up. The incidence of ROP is 40%. Gestational age (<37weeks) and low birth weight (2500g) are important risk factors for RO...
Journal of Kathmandu Medical College, 2016
Background: Retinopathy of prematurity is a vascular retinal disease that can cause blindness in premature new born babies. Several risk factors are associated with the incidence of ROP. Information and data on risk factors associated with ROP in context to Nepalese population is scarcely documented in literature. Objectives: The purpose of this study was to evaluate the risk factors of retinopathy of prematurity in premature infants admitted in the neonatal intensive care unit of Tribhuvan University Teaching Hospital. Methods: Neonates with gestational age of 36 weeks or less and birth weight of 2000 gram or less admitted to neonatal intensive care unit (NICU), during 2013 to 2015 were screened for retinopathy of prematurity. Risk factors and severity of retinopathy of prematurity were evaluated. The initial examination was carried out at 4-6 weeks after birth by indirect ophthalmoscope and retinopathy of prematurity positive and negative infants were compared subsequently. The Chi-square and independent t-tests were used for statistical analysis. A p value less than 0.05 was considered statistically signifi cant. Results: The incidence of retinopathy of prematurity was 22.6% and severe retinopathy of prematurity requiring treatment was observed in 3.2% of 93 neonates who had eye examinations. There was a signifi cant relationship between the occurrence of ROP and birth weight (p=0.000), gestational age (p=0.000), duration of oxygen therapy (p=0.009) and sepsis (p=0.002). However, insignifi cant relationship was observed between the occurrence of retinopathy of prematurity and gender, type of delivery, multiple gestation, premature rupture of foetal membrane, respiratory distress syndrome and hyperbilirubinaemia. Conclusion: The risk factors contributing to development of retinopathy of prematurity showed signifi cant relationship with immaturity, duration of oxygen supplementation and septicaemia.
Prevalence of retinopathy of prematurity among premature babies in a tertiary care hospital
International Journal of Research in Medical Sciences
Background: Retinopathy of prematurity (ROP) is a Vaso-proliferative retinal disease affecting low birth weight (BW) and premature infants which leads to blindness unless recognized and treated early. Aim was to study prevalence of ROP in babies <1500 gm and <32 weeks of gestation and stress the importance of examination of premature babies at four weeks after birth and regular follow up till the vascularization is complete. The aim was to determine the prevalence of ROP in premature babies in a tertiary care hospital.Methods: It is a prospective study carried out in premature babies referred for ophthalmological examination in eye OPD of govt. medical college Jammu over a period of one year. Babies with gestational age (GA) of <32 weeks at birth and BW<1500 gm, babies with gest age >32 weeks or BW>1500 gm were included if they were exposed to oxygen therapy for more than >7 days. Neonates with a BW<1500 g and GA<32 weeks who were referred for a ROP eye ex...
Sri Lanka Journal of Child Health, 2017
Introduction: Retinopathy of prematurity (ROP) chiefly affects preterm infants. With the increased survival of extremely preterm infants, the number of infants with severe ROP has also increased. Objective: To assess the incidence, associated factors and outcome of ROP in neonates born at less than 34 weeks of gestation and/or less than 1.5 kg birth weight in Sri Jayawardenepura General Hospital Method: A prospective, descriptive, observational study was conducted in neonates born from 01/01/2014 to 31/12/2014, who were less than 34 weeks of gestation and/or less than 1.5 kg birth weight. Data was collected from patient records. Incidence estimates were given using descriptive statistics. For bivariate analysis (where associated factors were considered), the Chi Square test was applied to assess significant associations. The level of significance was 0.05. Results: Of 126 neonates, 113 were included in study as 11 met exclusion criteria and 2 dropped out during follow up. Twenty eight (24.8%) neonates had ROP of whom 12 (42.9%) needed treatment. Study revealed that, earlier the gestation and lower the birth weight, ROP was more commonly observed. Patent ductus arteriosus (PDA) (p=0.006), sepsis (p=0.024), invasive ventilation for 7 or more days (p=0.0001) and supplementary oxygen for more than 7 days (p=0.0001) were significantly associated with development of ROP.
Prevalence of retinopathy of prematurity at tertiary care centre in Southern Rajasthan
IP Innovative Publication Pvt. Ltd, 2017
Introduction: Retinopathy of prematurity (ROP) is a proliferative retinopathy and a disease of premature infants. As the awareness about the risk factors increases amongst the neonatologist and ophthalmologist, adequate screening of preterm infants is being performed at tertiary care centers which can lead to a reduction in prevalence of ROP. Materials and Methods: 69 preterm infants born ≤ 34 week or birth weight ≤1700grams from January2015 to December 2016 were screened for ROP. Fundus was examined by indirect ophthalmoscopy with scleral indentation. Data was analyzed and the prevalence was calculated. Results: Out of total 69 infants, males were 43 (62.31%). Mean gestational age among males and females (in weeks) was 28.66 and 29.20 respectively. Mean birth weight among males and females (in grams) was 1346.90 and 1284.40 respectively. Prevalence of ROP was 1.44%. Conclusion: Prevalence of ROP is decreasing at tertiary care centers.