Antidiarrhoeal activity of the methanol extract of the barks of< i> Xylocarpus moluccensis in castor oil-and magnesium sulphate-induced diarrhoea models in mice (original) (raw)
The leaves of Calotropis procera R.Br was undertaken for evaluation of antidiarrhoeal activity in Albino mice (male) weighing between 40-50gm was used in this study. The selected and authenticated plant extract was prepared by maceration with using a methanol as a solvent for 7 days. From the toxicity study; it was observed that plant extract is non toxic and caused no death up to the dose of 500 mg/kg. It is safe and used for further experiment. The methanol extract of Calotropis procera showed significant activity against castor oil induced diarrhoea to compared standard drug Loperamide in albino mice. All the values obtained in the studies were expressed as mean ± SEM. by one way of analysis of variance for determining the significant difference. On the basis of these findings, it can be assumed that Calotropis procera R.Br could be a potential source for novel "lead" discovery for antidiarrhoeal drug development. Further study is necessary to evaluate the active principle responsible for the antidiarrhoeal activity and clear mechanism of action involved.
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