Plasmonic Diffraction Field Pattern Imaging Could Resolve Ultra-Sensitive Bio-Information (original) (raw)

ACS Photonics

Abstract

Subwavelength nanohole arrays have been very attractive for label-free biosensing applications, as they offer simplicity and flexibility in the read-out scheme. Recently, platforms employing imaging-based devices integrated to custom-made light sources and plasmonic nanohole array substrates have been proposed as strong candidates to increase throughput by allowing simultaneous evaluation of binding interactions. Despite their high-throughput and multiplexed nature, these platforms dramatically suffer from sensitivity compared to classical spectrometer-based systems. In this Letter, we introduced a highly sensitive and plasmonic imaging-based platform that can work with very low analyte concentrations. The system employs a tunable optic filter integrated to a CMOS camera that records diffraction intensity patterns of the transmitted light from a plasmonic biochip composed of periodic nanohole arrays. Monitoring diffraction field intensity variations that correspond to transmission values at different wave...

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