Central hemodynamics in relation to low-level environmental lead exposure (original) (raw)

Association of Blood Lead level with Elevated Blood Pressure in Hypertensive Patients

International journal of health sciences, 2011

Lead is a metal with many important industrial uses. The relationship between lead exposure and the rise of blood pressure has received a great deal of attention as it was implicated that the mortality from cardiovascular diseases might be reduced by lowering lead levels in the environment. The study was to investigate the correlation between the blood lead (B-Pb) levels and the values of blood pressure in hypertensive patients. Moreover, the plasma activities of angiotensin converting enzyme (ACE), plasma levels of nitric oxide (NO), total antioxidants (TAOX) and malondialdehyde (MDA) were estimated to investigate the correlations between the measured parameters and B-Pb levels in hypertensive patients. Fifty-five hypertensive patients were compared with fifty-three age and sex matched control group. The B-Pb levels were detected by flame atomic absorption spectrometry. The plasma levels of ACE activities, NO, TAOX and MDA were measured by colorimetric methods. In the hypertensive ...

Cumulative lead exposure, blood pressure, and pulse pressure: a longitudinal case-control study

Ziadi BOUKERMA, 2018

Background: The action of lead on blood pressure is always subject to discussion. To this, is added the possible action of the lead on the pulse pressure. Objective: To evaluate the effect of lead on blood pressure and pulse pressure by a longitudinal case-control study (275 exposed people and 282 controls). Method: The studied parameters of this study came from the medical follow-up records of the workers. Multivariate analyses and the study of survival time are made by SPSS version 20 software. Results: mean systolic and diastolic pressures were significantly higher (p<0.000) in lead-exposed workers than in controls. Ditto for pulsed pressure (p<0.000). There are almost two times more systolic and diastolic hypertension in lead-exposed workers. Survival was significantly much lower in the exposed cohort. Conclusion: The average lead as well as the cumulative lead act both on the pressure parameters.