TPMT*26 (208F→L), a novel mutation detected in a Chinese (original) (raw)

Abstract

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AI

TPMT*26 (208F→L) represents a novel mutation identified in a Chinese patient that correlates with reduced thiopurine methyltransferase (TPMT) enzyme activity and heightened sensitivity to the drug azathioprine, which is commonly used in autoimmune and transplant therapies. The study examines the genetic basis for azathioprine-related myelosuppression, revealing the significance of identifying genetic variants in diverse populations to prevent adverse drug reactions.

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