Investigation of the incidence of “undesirable” molecular moieties for high-throughput screening compound libraries in marketed drug compounds (original) (raw)
AI-generated Abstract
A database of 1070 marketed drug compounds was compiled and analyzed to assess the occurrence of "undesirable" moieties in relation to high-throughput screening compound libraries. The study found that 26% of these compounds contained at least one undesirable moiety, with electrophilic reactive groups being the most frequent. The results indicate that the presence of such moieties may not significantly obstruct clinical trials, and it is suggested that these compounds be flagged rather than eliminated from screening libraries.
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