Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes (original) (raw)
Faculty Opinions recommendation of Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Peter Van Endert
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2016
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XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice
Mark Koina
Diabetologia, 2022
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An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes
Carl Langefeld
Endocrinology, 2015
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Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes
Michelle Solomon
Biology direct, 2007
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Islet -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
S. Tersey, B. Maier
Diabetes, 2012
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Islet‐Immune Interactions in Type 1 Diabetes: The Nexus of Beta Cell Destruction
Todd Brusko
Clinical & Experimental Immunology
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Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes
Stefania Francesconi
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From immunobiology to β-cell biology: The changing perspective on type 1 diabetes
Raghavendra Mirmira
Islets, 2014
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Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
Massimo Pietropaolo
Journal of Theoretical Biology, 2014
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Aberrant islet unfolded protein response in type 2 diabetes
Trực Nguyễn
Scientific Reports, 2014
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Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes
Raghavendra Mirmira
Diabetes, obesity & metabolism, 2018
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β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Lars Krogvold
Diabetes
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Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
Décio Eizirik
Frontiers in Endocrinology, 2020
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Identification of Key β Cell Gene Signaling Pathways Involved in Type 1 Diabetes
Nikolai Petrovsky
Annals of the New York Academy of Sciences, 2004
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ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
Décio Eizirik
Upsala Journal of Medical Sciences, 2016
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Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
Raghavendra Mirmira
Endocrinology
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The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?
Scott Soleimanpour
Trends in endocrinology and metabolism: TEM, 2013
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Dynamic interaction between T cell-mediated -cell damage and -cell repair in the run up to autoimmune diabetes of the NOD mouse
Bruce Aronow
Physiological Genomics, 2005
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Beta cell DNA damage response promotes islet inflammation in type 1 diabetes
Lars Krogvold
2018
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Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?
Maria Lytrivi
Current Opinion in Pharmacology, 2018
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Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes
Truc Nguyen
Science Translational Medicine, 2013
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ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes
Bryan O'Sullivan-Murphy
Diabetes, 2012
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Genes Affecting β-Cell Function in Type 1 Diabetes
Simranjeet Kaur
Current Diabetes Reports, 2015
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Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
saurabh vig
Diabetologia, 2017
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Biomarkers of islet beta cell stress and death in type 1 diabetes
Raghavendra Mirmira
Diabetologia, 2018
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An islet in distress: β cell failure in type 2 diabetes
Raghavendra Mirmira
Journal of diabetes investigation, 2010
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Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes
Nataliya Lenchik
PLoS ONE, 2012
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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
maikel luis colli
Nature Genetics, 2019
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Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control
Simranjeet Kaur
Journal of Diabetes Research, 2016
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Type 2 Diabetes: Is it Time to Target β-cell Heterogeneity
Muthuswamy Balasubramanyam
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GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim
Cécile Julier, Daniel Cunha, Tatiane Nogueira
PLoS genetics, 2013
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Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice
Johnny Ludvigsson
Diabetes, 2003
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Inflammatory mechanisms in diabetes: lessons from the β-cell
Guoxun Chen
International Journal of Obesity, 2003
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