The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation (original) (raw)

This research investigates the differential effects of charged particle irradiation—specifically protons and carbon ions—compared to conventional X-ray irradiation on cancer cell survival and migration, emphasizing the implications of the Hedgehog (Hh) signaling pathway in these processes. Utilizing prostate cancer (PC3) and medulloblastoma (DAOY) cell lines, findings indicate that carbon ion therapy significantly reduces cell survival and migration while altering Hh pathway gene expression more effectively than X-rays or protons. Importantly, the Hh inhibitor GANT61 selectively sensitizes DAOY cells to particle radiation but not to X-rays, suggesting that therapeutic strategies combining Hh inhibitors with particle therapies require separate investigation. The study indicates a potential for enhanced treatment efficacy in specific cancer types through the combination of GANT61 and charged particle radiation.