New Strategies for Clinical Islet Transplantation (original) (raw)

The paper discusses recent advancements in clinical islet transplantation for diabetes treatment, focusing on the efficacy of islet preparation and the implications of exocrine contamination. Traditional methods aiming for pure islet extracts have been challenged by recent findings indicating that contaminated preparations may still yield successful engraftment and function. The authors argue for innovative immunosuppressive strategies that mitigate both immune damage to islet tissue and the potential diabetogenic effects of immunosuppressive drugs, making islet transplantation a viable alternative to pancreas transplantation.