Agreement between Endoscopic assessment and Histological Diagnosis of Helicobacter Pylori-Associated Gastric Atrophy and Intestinal Metaplasia (original) (raw)
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Medicine, 2018
Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer. Progression of lesions was evaluated according to H pylori status, age, and sex. Cox proportional hazard regression model and Kaplan-Meier curves were used to evaluate the strength of predictors for lesions progression.Among 105 patients (61 women) H pylori negative patients showed a milder worsening of gastric lesions between index and surveillance endosc...
Incidence of gastric cancer, its subtypes, and correlation with Helicobacter Pylori
Journal of Pathology of Nepal, 2013
Background: Gastric cancer is the fourth most commonly diagnosed cancer and the second most common cause of cancer related death worldwide. It is the common cause of cancer related death in Nepal. Helicobacter Pylori has been classified as a definite carcinogen along with other factors. The aim of this study was to fi nd the incidence of gastric cancer among the patients undergoing upper gastroscopy, its various subtypes and association with Helicobacter Pylori. Materials and Methods: This is a retrospective and prospective study carried out at GRP Polyclinic and Kist Medical College Teaching Hospital. All the patients undergoing upper gastrointestinal endoscopy were included in this study. Data of all the gastric endoscopic biopsies done from June 2011 to January 2013 were collected and analyzed. All the biopsy specimens were processed routinely in histopathology laboratory. Specimens showing carcinoma were enrolled in this study and all the relevant demographic data were collected...
Gastric cancer, Helicobacter pylori infection and other risk factors
World journal of gastrointestinal oncology, 2010
Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identified for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The definition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients.
Screening for gastric cancer in Asia: current evidence and practice
The Lancet Oncology, 2008
Gastric cancer is the second most common cause of death from cancer in Asia. Although surgery is the standard treatment for this disease, early detection and treatment is the only way to reduce mortality. This Review summarises the epidemiology of gastric cancer, and the evidence for, and current practices of, screening in Asia. Few Asian countries have implemented a national screening programme for gastric cancer; most have adopted opportunistic screening of high-risk individuals only. Although screening by endoscopy seems to be the most accurate method for detection of gastric cancer, the availability of endoscopic instruments and expertise for mass screening remains questionable-even in developed countries such as Japan. Therefore, barium studies or serum-pepsinogen testing are sometimes used as the initial screening tool in some countries, and patients with abnormal results are screened by endoscopy. Despite the strong link between infection with Helicobacter pylori and gastric cancer, more data are needed to defi ne the role of its eradication in the prevention of gastric cancer in Asia. At present, there is a paucity of quality data from Asia to lend support for screening for gastric cancer.
Life
Helicobacter pylori (H. pylori) infects about half of the world’s population and can lead to premalignant lesions and gastric cancer. Updated data about the correlation of histopathological diagnostics with endoscopic diagnostics are scarce. The objective of this study was to identify the concordance between endoscopic and histopathologic findings, with a focus on premalignant lesions. We performed a cross sectional, retrospective study over a 4-year period (2017–2021) on adult patients with dyspeptic symptoms and positive RUT (rapid urease test) in a single hospital centre, with a total of 133 patients infected with H. pylori being included in the study. Statistical associations between endoscopic appearance and histopathological results were found for atrophic antral gastritis (p = 0.001), intestinal metaplasia of the antrum (p = 0.018), gastric polyps (p < 0.001) and gastric corpus cancer (p = 0.012). Females were more likely to be diagnosed through endoscopy with gastric atro...
Gastroenterology & Hepatology Open Access, 2020
Infection with Helicobacter pylori (H. pylori) is common in developing countries such as Benin. This germ can cause several gastroduodenal diseases such as gastritis, ulcer, adenocarcinoma or gastric MALT lymphoma. This study aimed to determine the prevalence of H. pylori infection and gastric pre-neoplastic histological lesions in patients admitted for upper gastrointestinal endoscopy (UGE) and to identify factors associated with this infection. Methods: This was a cross-sectional descriptive and analytical study, with prospective data collection, conducted from October 2014 to December 2015. We included all patients admitted to Menontin Hospital for UGE in whom a gastric biopsy has been done. H. pylori research was conducted in anatomy-pathology, either in a medical laboratory in Cotonou or at the CERBA laboratory in Paris, France, depending on the patient's choice. The microscopic study was carried out after staining with Haematoxyline-Eosine-Safran (HES) and the search for H. pylori using Giemsa staining. Results: H. pylori was investigated in 137 patients, 67 men (48.9%) and 70 women (51.1%). The mean age was 48.3±14.6years with extremes of 10 and 83years. Some patients had had at least one previous H. pylori eradication treatment (63 cases or 46%). For the general population, the test was positive in 98 cases, i.e. a prevalence of 71.5%. Depending on whether or not patients had been pre-treated for H. pylori, the test was positive in 40 out of 63 (63.5%) pre-treated patients, versus 58 out of 74 (78.4%) patients who were naïve to any eradication treatment (p=0.057). The pre-neoplastic lesions noted were gastric atrophy in 35 patients (including 25 H. pylori positive), intestinal metaplasia in 13 patients (including 10 H. pylori positive) and low grade dysplasia in 14 patients (including 12 H. pylori positive); high grade dysplasia was found in one patient who was H. pylori negative. Only the type of prior eradicant treatment appeared to be associated with H. pylori infection (p=0.182). Conclusion: H. pylori infection is common in our patients admitted for upper gastrointestinal endoscopy. Gastric atrophy was the most common pre-neoplastic lesion.
Diagnostic and Therapeutic Endoscopy, 1997
Objective: The aim of the present study was to assess the prevalence of Helicobacter pylori (H. pylori) infection in Kashmiri patients with gastric cancer and to compare this with a matched control population.Methods: Fifty patients with gastric cancer and thirty age/sex matched controls were included in the study. All the subjects were hailing from Kashmir Valley. For detection of H. pylori, biopsy specimens were used both from cases and controls.Results: An insignificant association was shown between H. pylori and both intestinal and diffuse type of gastric cancer.Conclusions: The data provides support against the significant association between H. pylori and gastric cancer in this part of world, a place where the age standardized incidence of gastric cancer is alarmingly high. We conclude that other factors like personal and special dietary habits of Kashmiri population may be more important for the development of gastric cancer.
Cancer Causes & Control, 2013
Purpose Currently, studies on serologic diagnosis of Helicobacter pylori-associated gastric cancer (GC) in Latin America are scarce. The aim of the present study was to evaluate the association between H. pylori serology tests in patients with early precancerous lesions or GC, when compared with non-atrophic gastritis in Colombia, Paraguay, and Mexico, three countries in Latin America with a high prevalence of H. pylori infection but contrasting rates of GC mortality. Methods Gastric biopsies and blood samples were obtained from patients attending the gastroenterology or oncology services of hospitals in the three participating countries. IgG antibodies against H. pylori whole-cell antigens and CagA were tested in 1,117 sera using an enzyme-linked immunoabsorbent assay.
Detection of Helicobacter pylori in gastric cancer
Arquivos de Gastroenterologia, 2001
Background and Objectives — Considering the high prevalence of stomach cancer in the northern region of Brazil and the recognized relationship between chronic gastric inflammation caused by Helicobacter pylori, and its carcinogenic potential, the objective we had with this study was to investigate the presence of the microorganism in macro and microscopic presentations of neoplasm in different regions of the stomach, and in non-malignant lesions concomitant to the adenocarcinoma in patients originating from the metropolitan area of Belém (State of Pará, Brazil). Methods - Examinations were made on 172 patients divided into two groups: group I, formed by 75 patients with gastric carcinoma, and group II, formed by 97 patients with mild enanthematic gastritis, considered control group. The diagnosis was obtained during endoscopic examination and the respective biopsy. Gastric neoplasms were classified macroscopically in accordance with Borrmann's classification, and microscopically...